Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

TXA induces pain during surgery for AIS

14 Mar 2017

Tranexamic acid (TXA) administered during surgery for adolescent idiopathic scoliosis (AIS) evokes pain, requiring an increased infusion rate of remifentanil, a new study reports.

Researchers obtained records of AIS patients who received posterior spinal fusion surgery with pedicle screw constructs. Those older than 18 years at the time of surgery and who received the anterior procedure surgery were excluded.

Patients were stratified into two, according to whether they received intraoperative TXA or not. The primary outcome of the study was the infusion rate of intraoperative remifentanil, which was assumed to reflect pain reception during surgery.

Of the 75 patients included in the study, 42 received intraoperative TXA and 33 did not. Surgical data showed that the duration of the surgery and anaesthesia was significantly shorter in the TXA group compared with the control group (p<0.0001).

Similarly, the total volume of blood loss and intravascular fluid were significantly lower in the TXA group compared with the control group (p<0.0001). Moreover, patients who received TXA also required higher doses of ketamine and fentanyl compared with controls (p<0.05).

The mean infusion rate of intraoperative remifentanil was significantly higher in the TXA group (0.28±0.12 μg/kg/min) than in the control group (0.23±0.04 μg/kg/min; p=0.014).

In terms of ephedrine and phenylephrine consumption, haemoglobin levels and haemodynamic parameters, no difference between the groups was observed. No intra- and postoperative complications associated with TXA were observed.

The study highlights a new adverse event associated with TXA use and will help practitioners gauge the adequate dosage of TXA in surgeries.

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.