Most Read Articles
16 Jun 2016
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
5 days ago
Intra-articular injections of botulinum toxin-A deliver substantial short-term benefits in terms of pain reduction in patients with refractory joint pain, according to a meta-analysis.
6 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
Roshini Claire Anthony, 15 Jul 2017

Adding midostaurin to standard chemotherapy appeared to improve overall survival (OS) in patients recently diagnosed with acute myeloid leukaemia (AML) with a FLT3 mutation, according to a recent study.

TXA induces pain during surgery for AIS

14 Mar 2017

Tranexamic acid (TXA) administered during surgery for adolescent idiopathic scoliosis (AIS) evokes pain, requiring an increased infusion rate of remifentanil, a new study reports.

Researchers obtained records of AIS patients who received posterior spinal fusion surgery with pedicle screw constructs. Those older than 18 years at the time of surgery and who received the anterior procedure surgery were excluded.

Patients were stratified into two, according to whether they received intraoperative TXA or not. The primary outcome of the study was the infusion rate of intraoperative remifentanil, which was assumed to reflect pain reception during surgery.

Of the 75 patients included in the study, 42 received intraoperative TXA and 33 did not. Surgical data showed that the duration of the surgery and anaesthesia was significantly shorter in the TXA group compared with the control group (p<0.0001).

Similarly, the total volume of blood loss and intravascular fluid were significantly lower in the TXA group compared with the control group (p<0.0001). Moreover, patients who received TXA also required higher doses of ketamine and fentanyl compared with controls (p<0.05).

The mean infusion rate of intraoperative remifentanil was significantly higher in the TXA group (0.28±0.12 μg/kg/min) than in the control group (0.23±0.04 μg/kg/min; p=0.014).

In terms of ephedrine and phenylephrine consumption, haemoglobin levels and haemodynamic parameters, no difference between the groups was observed. No intra- and postoperative complications associated with TXA were observed.

The study highlights a new adverse event associated with TXA use and will help practitioners gauge the adequate dosage of TXA in surgeries.

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Most Read Articles
16 Jun 2016
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
5 days ago
Intra-articular injections of botulinum toxin-A deliver substantial short-term benefits in terms of pain reduction in patients with refractory joint pain, according to a meta-analysis.
6 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
Roshini Claire Anthony, 15 Jul 2017

Adding midostaurin to standard chemotherapy appeared to improve overall survival (OS) in patients recently diagnosed with acute myeloid leukaemia (AML) with a FLT3 mutation, according to a recent study.