Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.

Tumour multifocality offers no risk prognostic value in PTC outcomes

10 Oct 2017

It appears that tumour multifocality does not predict clinical outcomes of papillary thyroid cancer (PTC), suggests a recent study.

“Multifocality is often treated as a risk factor for PTC, prompting aggressive treatments,” according to researchers.

To determine the prognostic value of tumour multifocality in clinical outcomes of PTC, the investigators recruited 2,638 patients (median age 46 years; 2,015 women) and followed them for a median 58 months at 11 medical centres in six countries. The Surveillance, Epidemiology and End Results (SEER) data was used for validation.

Disease recurrence was 198 of 1,000 (19.8 percent) in multifocal and 221 of 1,624 (13.6 percent) in unifocal PTC (hazard ratio [HR], 1.55; 95 percent CI, 1.28 to 1.88; p<0.001). This became insignificant after multivariate adjustment (HR, 1.13; 0.93 to 1.37).

The results were comparable in PTC variants, including conventional PTC, follicular-variant PTC, tall-cell PTC and papillary thyroid microcarcinoma. No association existed between multifocality and mortality in any of these PTC settings. However, classic risk factors strongly predicted cancer recurrence or mortality, and this association remained significant after multivariate adjustment.

In patients with intrathyroidal PTC (n=1,423), disease recurrence was 20 of 455 (4.4 percent) and 41 of 967 (4.2 percent; p=0.892) and mortality was zero of 455 (0.0 percent) and three of 967 (0.3 percent; p=0.556) in multifocal and unifocal PTC, respectively.

“The results were reproduced in 89,680 patients with PTC in the SEER database,” according to researchers.

The indiscriminate use of tumour multifocality as an independent risk factor, prompting overtreatment of patients, should be avoided, they added.

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Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.