Most Read Articles
13 Oct 2017
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
12 Oct 2017
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
6 days ago
Excessive intake of the mineral manganese can be toxic to the heart, according to a new study.

Tuberculosis carries increased risk of peripheral arterial disease

09 Aug 2017

Patients with tuberculosis (TB) are at greater risk of developing peripheral arterial disease (PAD) than those who do not have the infection, a population-based cohort study from Taiwan suggests.

Researchers examined the medical records of 14,350 patients with TB and 28,700 matched controls drawn from the Taiwan National Health Insurance Database between 2000 and 2010. Cox proportional hazards regression models were used to estimate the risk of PAD.

Compared with non-TB controls, patients with the infection had a 3.93-fold higher risk of developing PAD. This relationship was independent of age, sex, comorbidities and socioeconomic status. Furthermore, the excess risk of PAD among patients with TB persisted after the first year of follow-up.

PAD affects the noncoronary arteries, especially the arteries supplying the limbs. The disease frequently results from atherosclerosis, but may also be secondary to cardiac or vascular embolism, vasculitis, hypercoagulopathy, vascular dissection and vascular compression syndromes, among others. [Circulation 2012;125:3220–3228]

Previous reports have implicated TB in PAD, and the pathogenic mechanisms typically involved in infection include increased expression of proinflammatory cytokines and immune activation potentially promoting atherogenesis. [Nat Rev Cardiol 2017;14:156–170]

Given the current finding that TB presents an increased risk of PAD, the infection should be considered when evaluating a patient's risk of developing PAD, researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
13 Oct 2017
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
12 Oct 2017
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
6 days ago
Excessive intake of the mineral manganese can be toxic to the heart, according to a new study.