Most Read Articles
09 Oct 2017
Pleural fluid lactic dehydrogenase (LDH) and glucose are useful parameters for evaluating severity of paediatric community acquired complicated pneumonia (PCACP), according to a study. Measurements of both parameters strongly correlate with prolonged hospitalization as an indirect indicator of disease severity.
5 days ago
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
6 days ago
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
Elaine Tan, 14 Aug 2017

Complicated and uncomplicated urinary tract infections (UTIs) in adults and children should be managed by identifying and treating predisposing or underlying risk factors, with antimicrobial treatment, if needed, based on urine culture results and regional antibiotic resistance patterns, according to new guidelines of the Urological Association of Asia (UAA) and Asian Association of UTI and STD (AAUS).

Tuberculosis carries increased risk of peripheral arterial disease

09 Aug 2017

Patients with tuberculosis (TB) are at greater risk of developing peripheral arterial disease (PAD) than those who do not have the infection, a population-based cohort study from Taiwan suggests.

Researchers examined the medical records of 14,350 patients with TB and 28,700 matched controls drawn from the Taiwan National Health Insurance Database between 2000 and 2010. Cox proportional hazards regression models were used to estimate the risk of PAD.

Compared with non-TB controls, patients with the infection had a 3.93-fold higher risk of developing PAD. This relationship was independent of age, sex, comorbidities and socioeconomic status. Furthermore, the excess risk of PAD among patients with TB persisted after the first year of follow-up.

PAD affects the noncoronary arteries, especially the arteries supplying the limbs. The disease frequently results from atherosclerosis, but may also be secondary to cardiac or vascular embolism, vasculitis, hypercoagulopathy, vascular dissection and vascular compression syndromes, among others. [Circulation 2012;125:3220–3228]

Previous reports have implicated TB in PAD, and the pathogenic mechanisms typically involved in infection include increased expression of proinflammatory cytokines and immune activation potentially promoting atherogenesis. [Nat Rev Cardiol 2017;14:156–170]

Given the current finding that TB presents an increased risk of PAD, the infection should be considered when evaluating a patient's risk of developing PAD, researchers said.

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Most Read Articles
09 Oct 2017
Pleural fluid lactic dehydrogenase (LDH) and glucose are useful parameters for evaluating severity of paediatric community acquired complicated pneumonia (PCACP), according to a study. Measurements of both parameters strongly correlate with prolonged hospitalization as an indirect indicator of disease severity.
5 days ago
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
6 days ago
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
Elaine Tan, 14 Aug 2017

Complicated and uncomplicated urinary tract infections (UTIs) in adults and children should be managed by identifying and treating predisposing or underlying risk factors, with antimicrobial treatment, if needed, based on urine culture results and regional antibiotic resistance patterns, according to new guidelines of the Urological Association of Asia (UAA) and Asian Association of UTI and STD (AAUS).