Most Read Articles
3 months ago
Use of transcutaneous electrical nerve stimulation (TENS) in combination with oxybutynin in the treatment of urge incontinence in children is superior to both TENS and oxybutynin monotherapy in terms of efficacy, a study has shown. Treatment with TENS also helps reduce the risk of oxybutynin-induced elevated postvoid residual urine volume.
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Dr. Joseph Delano Fule Robles, 11 months ago

Patients with localized prostate cancer achieve similar functional and pathologic outcomes with robot-assisted laparoscopic prostatectomy (RALP) or open radical retropubic prostatectomy, early results of the first trial comparing the two techniques have shown.

Triptorelin better than surgical castration in lowering testosterone levels

2 months ago
prostate cancer, Ejaculation frequency, prostate stagnation hypothesis

Compared with subcapsular orchiectomy, 24-week depot triptorelin injections significantly reduce testosterone levels, according to a Danish study.

“To our knowledge this is the first randomized study to demonstrate a difference in treatment effect between surgical and medical castration on testosterone levels,” researchers said.

A total of 58 consecutive hormone naïve men diagnosed with advanced prostate cancer from September 2013 to March 2015 were randomly assigned 1:1 to either subcapsular orchiectomy or triptorelin 22.5 mg given as 24-week depot injections. Follow-up was 48 weeks.

Liquid chromatography-tandem mass spectrometry was used to measure androgen status prior to treatment and after 12, 24, and 48 weeks. Longitudinal Tobit regression was used to analyse between-group differences in achieved hormone levels.

Patients treated with the luteinizing hormone-releasing hormone agonist triptorelin had 29-percent lower testosterone levels (95 percent CI, 17.2 to 41.7) compared to subcapsular orchiectomy (p<0.001). Compared to men undergoing orchiectomy, a significantly higher proportion of men receiving triptorelin had testosterone levels <20 ng/dl at weeks 12 (97 vs 79 percent) and 48 (100 vs 87 percent; p<0.05).

No detectable difference was observed in the adrenal androgen reduction between the two treatment groups.

“Recent evidence suggests that reaching the lowest achievable levels of testosterone with androgen deprivation therapy delays disease progression and increases overall survival in men with advanced prostate cancer,” according to researchers.

In a previous study, participants on luteinizing hormone-releasing hormone agonist therapy showed significantly lower testosterone levels than men who underwent surgical castration. All patients had serum testosterone values <50 ng/dl and 97 percent had testosterone concentrations <20 ng/dl. [J Urol 2012;187:1601-6]

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Most Read Articles
3 months ago
Use of transcutaneous electrical nerve stimulation (TENS) in combination with oxybutynin in the treatment of urge incontinence in children is superior to both TENS and oxybutynin monotherapy in terms of efficacy, a study has shown. Treatment with TENS also helps reduce the risk of oxybutynin-induced elevated postvoid residual urine volume.
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7 months ago
Therapy regimens with add-on mirabegron may be safely used in children with refractory overactive bladder, according to data from a prospective off-label study.
Dr. Joseph Delano Fule Robles, 11 months ago

Patients with localized prostate cancer achieve similar functional and pathologic outcomes with robot-assisted laparoscopic prostatectomy (RALP) or open radical retropubic prostatectomy, early results of the first trial comparing the two techniques have shown.