Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Triglyceride to HDL-C ratio may predict cardiovascular events in T2DM patients with CAD

26 Sep 2017
A recent study shows that diabetes drugs are not only beneficial for the targeted disease, it can also lower the risk of heart failure and renal disease.

Elevated values of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio appear to predict future cardiovascular events (CVE) in Chinese type 2 diabetes mellitus (T2DM) patients with coronary artery disease (CAD), a recent study has shown.

The study included 1,447 consecutive T2DM patients with stable CAD, as confirmed by angiography. Over an average follow-up period of 20.3 months, 96 patients had CVEs.

The most common CVE was myocardial revascularization procedures because of clinical deterioration, reported in 57.3 percent (n=55). This was followed by nonfatal myocardial infarction (MI, 19.8 percent; n=19), stroke (15.6 percent; n=15) and cardiac deaths (7.3 percent; n=7).

The log of the TG/HDL-C at baseline was significantly associated with subsequent CVEs (hazard ratio [HR], 2.47; 95 percent CI, 1.01 to 6.04; p=0.047) even after adjusting for other CVD risk factors such as sex, BMI, total cholesterol and blood pressure.

Baseline HbA1c levels were also significantly associated with subsequent CVE development (HR, 1.20; p=0.009) after adjusting for sex and age. When smoking status, total cholesterol and left ventricle ejection fraction were included in the model, the significant association was disrupted.

The study included patients hospitalized for T2DM and had stable CAD. Exclusion criteria included acute coronary syndrome, systemic inflammatory diseases, thyroid dysfunction, renal insufficiency, malignancies and familial hypercholesterolaemia, among others.

For the purposes of the study, CVEs were defined as strokes, cardiac death, coronary artery bypass graft, percutaneous coronary intervention and nonfatal MI.

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Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.