Triglyceride to HDL-C ratio may predict cardiovascular events in T2DM patients with CAD
Elevated values of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio appear to predict future cardiovascular events (CVE) in Chinese type 2 diabetes mellitus (T2DM) patients with coronary artery disease (CAD), a recent study has shown.
The study included 1,447 consecutive T2DM patients with stable CAD, as confirmed by angiography. Over an average follow-up period of 20.3 months, 96 patients had CVEs.
The most common CVE was myocardial revascularization procedures because of clinical deterioration, reported in 57.3 percent (n=55). This was followed by nonfatal myocardial infarction (MI, 19.8 percent; n=19), stroke (15.6 percent; n=15) and cardiac deaths (7.3 percent; n=7).
The log of the TG/HDL-C at baseline was significantly associated with subsequent CVEs (hazard ratio [HR], 2.47; 95 percent CI, 1.01 to 6.04; p=0.047) even after adjusting for other CVD risk factors such as sex, BMI, total cholesterol and blood pressure.
Baseline HbA1c levels were also significantly associated with subsequent CVE development (HR, 1.20; p=0.009) after adjusting for sex and age. When smoking status, total cholesterol and left ventricle ejection fraction were included in the model, the significant association was disrupted.
The study included patients hospitalized for T2DM and had stable CAD. Exclusion criteria included acute coronary syndrome, systemic inflammatory diseases, thyroid dysfunction, renal insufficiency, malignancies and familial hypercholesterolaemia, among others.
For the purposes of the study, CVEs were defined as strokes, cardiac death, coronary artery bypass graft, percutaneous coronary intervention and nonfatal MI.