Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Traumatic life events affect cellular ageing in women of reproductive age

14 Jul 2017
Women of reproductive age who suffer a traumatic life event such as the loss of a child have a faster pace of cellular ageing than those who do not, and this appears to be affected by maternal hypothalamic-pituitary-adrenal axis (HPAA) activity, say Canada-based researchers.

They tested the hypothesis that psychological challenges increase the age-related pace of biological ageing by measuring telomere attrition in a cohort of Kaqchikel Mayan women living in a population with a high frequency of child mortality. The women are part of an ongoing longitudinal study of the relationship between naturally occurring stress and women’s reproductive function. Genetic variability was reduced since the women were all Kaqchikel Mayan with at least five generations of traceable ancestors. Moreover, they had similar lifestyles in terms of diet, physical activity, education, and socioeconomic status, and none smoked.

Telomere length was quantified by qPCR of buccal specimens collected from 55 women in 2013, and HPAA activity was assessed by quantifying cortisol levels in first morning urinary specimens collected every other day for 7 weeks during that same year. Child mortality data were collected in 2000 and 2013.

Only women who experienced child mortality were found to have shorter telomere lengths with increasing age (p=0.015). Notably, shorter telomere length was linked to higher than average basal cortisol levels (p=0.007) as well as greater variations in basal cortisol levels over time (p=0.053). Nonparametric bootstrapping analyses indicated that HPAA activity mediated the effect of child mortality on telomere length.

The researchers suggested that more large-scale longitudinal studies are required to confirm their findings.
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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.