Most Read Articles
Fiel Soliven, 01 Apr 2015
The effects canagliflozin on serum acid levels of type 2 diabetes mellitus patients and a subset who have hyperuricaemia were assessed in this review article.
16 Jun 2016
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
3 days ago
Intra-articular injections of botulinum toxin-A deliver substantial short-term benefits in terms of pain reduction in patients with refractory joint pain, according to a meta-analysis.
4 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.

Tolterodine, solifenacin, oxybutynin use tied to increased risk of dementia

21 Apr 2017

Subsequent dementia is associated with taking tolterodine, solifenacin and particularly oxybutynin in patients with diabetes mellitus, a new study shows.

The study retrieved records of 10,938 patients who had received at least one type of oxybutynin, tolterodine or solifenacin from the Taiwan National Health Insurance Research Database. An age-, sex- and index date-matched control cohort was established on a 1:1 ratio. Those diagnosed with dementia before the index date or within 180 days were excluded.

Comorbidities included in the analysis were hypertension, lipid disorders, atrial fibrillation, chronic kidney diseases, coronary artery disease and heart failure.

Dementia was reported in 7,774 at the end of the follow-up period. For the oxybutynin, solifenacin and tolterodine groups, the 6-year dementia rates were 3.9, 4.3 and 2.2 percent, respectively. These rates were significantly different compared with the control group (1.2 percent; p<0.001).

After age- and sex-matching, only 2,540 patients were eligible for analysis. The 6-year dementia rates for this group decreased for oxybutynin (3.0 percent) and solifenacin (3.5 percent). Interestingly, the rate increased in controls (2.4 percent) to a level that was higher than that reported in tolterodine users (2.3 percent).

According to the failure curve, dementia was significantly more likely to occur in patients who took oxybutynin, solifenacin or tolterodine (p<0.001 for all).

After adjusting for confounders, the competing-risk regression model showed that those who received oxybutynin (adjusted hazard ratio [aHR], 2.35; 95 percent CI, 1.96 to 2.81), solifenacin (aHR, 2.16; 1.81 to 2.58) and tolterodine (aHR, 2.24; 1.85 to 2.73) were at higher risks of dementia, with death as the competing event. Of the three drugs, solifenacin showed the lowest risk.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacy - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Fiel Soliven, 01 Apr 2015
The effects canagliflozin on serum acid levels of type 2 diabetes mellitus patients and a subset who have hyperuricaemia were assessed in this review article.
16 Jun 2016
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
3 days ago
Intra-articular injections of botulinum toxin-A deliver substantial short-term benefits in terms of pain reduction in patients with refractory joint pain, according to a meta-analysis.
4 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.