Most Read Articles
11 days ago
Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.
3 days ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
5 days ago
Myopia is associated with depressive symptoms in Chinese adults, a new population-based study shows.
5 days ago
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.

Tofacitinib show efficacy in treatment of severe alopaecia

5 months ago

Tofacitinib has a potential to treat severe alopaecia areata (AA), alopaecia totalis and alopaecia universalis, suggests a recent study.

A common autoimmune disorder, AA has no reliably effective therapies, according to researchers.

A retrospective study was conducted to assess the safety and efficacy of the Janus kinase 1/3 inhibitor tofacitinib in a series of patients over an extended period of time. Included were individuals (aged ≥18 years; n=90) with AA with at least 40 percent scalp hair loss treated with tofacitinib.

The percent change in Severity of Alopecia Tool (SALT) score during treatment was the primary endpoint.

There was a total of 65 potential responders to therapy. These responders were defined as patients with alopaecia totalis or alopaecia universalis with duration of current episode of disease of ≤10 years, or AA. Of these, 77 percent achieved a clinical response, with 58 percent of patients achieving more than 50-percent change in SALT score over 4 to 18 months of treatment.

A higher percent change in SALT score was achieved by patients with AA compared with those with alopaecia totalis or alopaecia universalis (81.9 vs 59.0 percent).

Tofacitinib was well tolerated, and no serious adverse events were recorded.

The study was limited by the retrospective nature of the data, the relatively small number of patients and lack of a control group, according to researchers, adding that randomized controlled trials are warranted to better define tofacitinib dose response.

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Most Read Articles
11 days ago
Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.
3 days ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
5 days ago
Myopia is associated with depressive symptoms in Chinese adults, a new population-based study shows.
5 days ago
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.