Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.

TNFR 1, 2 linked to all-cause, cardiovascular mortality in haemodialysis

12 Mar 2017

The risk of all-cause and cardiovascular mortality among end-stage renal disease patients receiving haemodialysis may be associated with increased levels of the circulating tumour necrosis factor receptors (TNFR), a new study reports.

The study included 319 patients undergoing haemodialysis. Only those who were clinically stable and with baseline serum data were included; those who had advanced dementia, were hospitalized two months prior or received haemodialysis for <1 month were excluded.

The primary outcomes were cardiovascular and all-cause mortality. These included mortalities from myocardial infarction, arrhythmia, stroke and congestive heart failure. Enzyme-linked immunosorbent assay was used to measure TNFR 1, 2 and total TNF-α levels.

Of the participants, 60.8 percent were male and 50.2 percent had diabetes. After a median follow-up period of 53 months, 72.4 percent of the participants remained alive. Of those who died, 45.5 percent died because of cardiovascular diseases.

Univariate analysis showed that all-cause mortality was significantly associated with both TNFRs (TNFR1: hazard ratio [HR], 2.42; 95 percent CI, 1.58 to 3.70; p<0.0001; TNFR2: HR, 2.70; 1.77 to 4.13; p<0.0001) but not with TNF-α. This trend remained significant even after controlling for other variables like age, blood pressure and prior cardiovascular diseases (TNFR1: HR, 2.34; 1.50 to 3.64; p<0.0001; TNFR2: HR, 2.13; 1.38 to 3.29; p<0.0001).

Only TNFR1 showed significant association with cardiovascular mortality after controlling for variables (HR, 2.15; 1.13 to 4.10; p=0.02).

The findings thus show a correlation between all-cause and cardiovascular mortality and circulating TNFRs in end-stage renal disease patients undergoing haemodialysis.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.