Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
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01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

TNFi monotherapy initiation in PsA patients decline despite efficacy

24 Feb 2017

There have been significant changes in the treatment patterns among patients with psoriatic arthritis (PsA) from 2004 to 2012, according to a recent study.

Patients remain persistent with the use of tumor necrosis factor inhibitor (TNFi) monotherapy, but physicians are not more likely to initiate it despite an increase in clinical evidence over this study period supporting its effectiveness.

To improve understanding of current practices in the treatment management of patients with PsA, an observational study was conducted based on data from the Corrona registry of adult patients with PsA in North America collected between 1 January 2004 and 31 December 2012.

Researchers divided the participants (n=520) into three therapy cohorts: TNFi monotherapy (n=190), methotrexate (MTX) monotherapy (n=217) and TNFi-MTX combination therapy (n=113). Patients were further classified into three study periods to understand changes over time: 2004 to 2006 (n=110), 2007 to 2009 (n=192) and 2010 to 2012 (n=218).

For the analysis, researchers collected data on persistence, discontinuation, restarting, switching, adding/dropping therapy and dose stretching.

A decrease in the proportion of patients initiating TNFi monotherapy occurred over time, but the proportion initiating combination therapy remained constant.

Participants who were persistent also decreased over time across all therapy cohorts, but the percentage of patients remained higher in TNFi monotherapy than in other therapy groups. In addition, the duration of persistence declined over time.

Compared with patients in the TNFi monotherapy cohort, those initiating MTX monotherapy were more likely to add therapy, according to researchers.

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Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
Please click here to access this module
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.