Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS. 
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

TNFi effectiveness: nonradiographic axial spondyloarthritis vs ankylosing spondylitis

6 months ago

Subjective disease activity is higher in patients with nonradiographic axial spondyloarthritis (nr-axSpA) at start of tumour necrosis factor inhibitor (TNFi) treatment, but outcomes are similar to patients with ankylosing spondylitis (AS) after adjusting for confounders, according to a nationwide cohort study.

In addition, HLA-B27 positivity is associated with better outcomes regardless of axSpA subdiagnosis.

Researchers conducted an observational cohort study based on data from the nationwide DANBIO registry to compare baseline disease activity and treatment effectiveness in biologic-naïve patients with nr-axSpA and AS who started TNFi treatment, as well as to analyse the role of potential confounders (sex/age/start yr/HLA-B27/disease duration/TNFi-type/smoking/baseline disease activity).

Kaplan-Meier plots, Cox and logistic regression analyses were used to assess the effect of diagnosis (nr-axSpA vs AS) and potential confounders on TNFi adherence and response (eg, Bath Ankylosing Spondylitis Activity Index [BASDAI] 50 percent/20 mm).

At TNFi initiation, nr-axSpA patients had higher visual analogue scale scores, compared with AS patients, for pain (median 72 vs 65 mm), global (76 vs 68 mm), fatigue (74 vs 67 mm) and BASDAI (64 vs 59; p<0.01 for all). Patients with nr-axSpA, however, had lower C-reactive protein (7 vs 11 mg) and BAS Metrology Index (20 vs 40; p<0.01 for all).

Median treatment adherence was poorer in nr-axSpA than in AS patients (1.59 years; 95 percent CI, 1.15 to 2.02 vs 3.67 years; 2.86 to 4.49; p<0.0001) in univariate analysis, but not in confounder-adjusted analysis (p>0.05). Both nr-axSpA and AS groups had similar response rates (p>0.05).

HLA-B27 negativity correlated with poorer treatment adherence (HLA-B27 negative/positive, nr-axSpA: hazard ratio [HR], 1.74; 1.29 to 2.36; AS: HR, 2.04; 1.53 to 2.71; p<0.0001 for both) and lower response rates (nr-axSpA: 30 vs 55 percent; AS: 29 vs 54 percent; both p<0.05).

A total of 1,250 TNFi-naïve patients with axSpA were included in the study. Patients with nr-axSpA were more frequently women (50/27 percent) and HLA-B27–negative (25 percent), compared to AS (17 percent; p<0.01).

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Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS. 
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.