Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
2 years ago
A study on participants from the Women's Health Initiative showed the dissociation between calcium/vitamin D supplementation and reduction in menopausal symptoms.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS. 

TNF inhibitors may slightly increase risk of developing severe extra-articular RA

17 days ago

Patients treated with tumour necrosis factor (TNF) inhibitors are marginally prone to develop severe extra-articular rheumatoid arthritis (ExRA), a study suggests. In addition, rheumatoid factor (RF)-positive patients with disabling disease of long duration are at an increased risk of developing severe ExRA.

Researchers recruited a dynamic community-based cohort of patients with RA (n=1,977) to assess whether treatment with TNF inhibitors affected the risk of developing severe ExRA manifestations, as well as to study potential predictors for developing ExRA. They reviewed clinical records and identified cases of severe ExRA. Information on exposure to TNF inhibitors was obtained from a regional register.

Analysis of exposure to TNF inhibitors was done in a time-dependent fashion. Additionally, researchers compared the incidence of severe ExRA in exposed patients with the incidence in those who were unexposed. Cox regression models were used to evaluate possible predictors of severe ExRA.

A total of 17 patients had new onset of severe ExRA during treatment with TNF inhibitors in 2,400 person-years at risk (0.71/100; 95 percent CI, 0.41 to 1.13) compared with 104 in 15,599 person-years (0.67/100; 0.54 to 0.81) in those without TNF inhibitors, corresponding to an incidence rate ratio of 1.06 (0.60 to 1.78).

Anti-TNF‒treated patients had a hazard ratio for ExRA of 1.21 (1.02 to 1.43), adjusted for age and sex; the findings were similar in models adjusted for time-dependent Health Assessment Questionnaire and propensity for anti-TNF treatment.

The predictors for ExRA were male sex, positive RF, long disease duration and greater disability, according to researchers.

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Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
2 years ago
A study on participants from the Women's Health Initiative showed the dissociation between calcium/vitamin D supplementation and reduction in menopausal symptoms.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS.