Most Read Articles
Elvira Manzano, 20 Feb 2017
Serum alpha-fetoprotein (AFP) can be a surrogate biomarker for predicting stages of hepatic fibrosis and cirrhosis in patients with chronic hepatitis C without hepatocellular carcinoma (HCC), according to a new study presented at the APASL 2017 meeting, highlighting the value of this glycoprotein in fibrosis staging.
Roshini Claire Anthony, 26 May 2016
Antibiotic prophylaxis is safe and effective in reducing surgical site and global infections in low-risk patients undergoing elective laparoscopic cholecystectomy, a recent study found.
Tristan Manalac, 18 Sep 2017
In malaria caused by Plasmodium knowlesi, age appears to be strongly associated with parasitaemia, systemic inflammation, endothelial activation, microvascular dysfunction and disease severity, according to a recent study.
01 Nov 2013

Urinary tract infections (UTI) are reported to be the most common reason for women to visit their healthcare professionals. The urinary tract, the body’s system that produces, stores and eliminates urine, is made up of the kidneys, ureters, bladder and urethra.

Timing of probiotic administration modifies CDI risk in hospitalized patients

23 Feb 2017

The risk of Clostridium difficile infection (CDI) in hospitalized patients may be halved by a strategy of administering probiotics within 2 days of antibiotic initiation, according to the results of a systematic review.

Researchers searched databases for trials examining the association between probiotic use and CDI in hospitalized adult patients receiving antibiotics. CDI incidence and adverse events were the primary and secondary outcomes of interest, respectively. The bias risk and overall evidence quality, as well as the effects of probiotic species, dose, timing, formulation and duration were also assessed.

The pooled data from 19 studies involving 6,261 patients showed that the group of those who received probiotics (n=3,277) had a lower CDI incidence compared with the control group (n=2,984; 1.6 vs 3.9 percent; p<0.001). Probiotic use was associated with a 58-percent reduction in the risk of CDI (relative risk [RR], 0.42; 95 percent CI, 0.30 to 0.57; I2=0.0 percent).

The CDI risk-lowering effect was significantly greater when probiotics were given within 2 days of antibiotic initiation (RR, 0.32; 0.22 to 0.48; I2=0 percent) than when given at a later time (RR, 0.70; 0.40 to 1.23; I2=0 percent; p=0.02). There was an observed decrement in efficacy for each day of delay in administering probiotics (p=0.04).  

Probiotics did not appear to increase the risk of adverse events, and the overall quality of the evidence was high.

Comprising live or live-attenuated microorganisms that provide a health benefit to the host, probiotics act against C. difficile by potentially suppressing germination, colonization and adhesion of bacterial spores or vegetative cells and by inhibiting its toxins. Probiotics also helps stimulate immune function, enhance barrier function and prevent epithelial cell apoptosis. [Chen X, et al. Mechanisms of action and applications of probiotics for the treatment of Clostridium difficile infection. In: Méndez-Vilas A, ed. Microbial pathogens and strategies for combating them: science, technology and education. Formatex Research Center: 2013]

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Most Read Articles
Elvira Manzano, 20 Feb 2017
Serum alpha-fetoprotein (AFP) can be a surrogate biomarker for predicting stages of hepatic fibrosis and cirrhosis in patients with chronic hepatitis C without hepatocellular carcinoma (HCC), according to a new study presented at the APASL 2017 meeting, highlighting the value of this glycoprotein in fibrosis staging.
Roshini Claire Anthony, 26 May 2016
Antibiotic prophylaxis is safe and effective in reducing surgical site and global infections in low-risk patients undergoing elective laparoscopic cholecystectomy, a recent study found.
Tristan Manalac, 18 Sep 2017
In malaria caused by Plasmodium knowlesi, age appears to be strongly associated with parasitaemia, systemic inflammation, endothelial activation, microvascular dysfunction and disease severity, according to a recent study.
01 Nov 2013

Urinary tract infections (UTI) are reported to be the most common reason for women to visit their healthcare professionals. The urinary tract, the body’s system that produces, stores and eliminates urine, is made up of the kidneys, ureters, bladder and urethra.