Most Read Articles
24 days ago
Regardless of dosing, nonvitamin K antagonist oral anticoagulants (NOACs) are more effective than warfarin for atrial fibrillation and safer in Asian than in non-Asian populations, a new meta-analysis shows.
9 days ago
In a Japanese population, highly myopic eyes show greater increases in axial length than nonmyopic eyes, a new retrospective longitudinal study shows. In particular, eyes with myopic choroidal neovascularization (CNV) show the greatest increases.
6 days ago
Compared with the lowest scores, the highest low-carbohydrate diet scores are associated with a 17 percent higher risk of diabetes mellitus, according to a new meta-analysis.
5 days ago
Children with sleep apnoea have significantly higher risks of developing depressive disorders than those without the sleep disorder, a new retrospective cohort study reveals.

Time to retreatment in eyes with nAMD after pause in therapy

7 months ago

A recent study offers times to retreatment in eyes with neovascular age-related macular degeneration (nAMD) that has been treatment-free for intervals of 3 to 12 months and demonstrates the likelihood of repeat therapy within the next year even after a treatment-free interval (TFI) of 12 months.

Researchers conducted a multicentre national nAMD database study to identify time to retreatment in eyes with nAMD that had been treatment-free for intervals of 3, 6, 9 and 12 months during the maintenance phase of ranibizumab therapy within the UK National Health Service. They collected structured data from 14 centres, involving 12,951 eyes receiving 92,976 ranibizumab injections.

Three fixed, monthly infection in a loading phase of treatment were administered to patients, followed by a pro re nata retreatment regimen in a maintenance phase. Eyes with TFI of 3, 6, 9 and 12 months in the maintenance phase were identified and the time to retreatment after these TFIs was determined.

For the 20th and 50th centiles, the time to retreatment was 0.58/2.54 months after a 3-month TFI, 2.07/9.62 months after a 6-month TFI, 3.69/15.84 months after a 9-month TFI and 5.90/22.49 months after a 12-month TFI.

Following a TFI of 3, 6, 9 and 12 months, respective retreatments were required for 68, 44, 31 and 21 percent of eyes after an additional 6 months of follow-up. Likewise, 77, 56, 43 and 34 percent of these eyes needed retreatment after 12 months of follow-up.

These findings can help plan appropriate follow-up intervals for patients who have been treatment-free for an interval of up to 1 year, according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
24 days ago
Regardless of dosing, nonvitamin K antagonist oral anticoagulants (NOACs) are more effective than warfarin for atrial fibrillation and safer in Asian than in non-Asian populations, a new meta-analysis shows.
9 days ago
In a Japanese population, highly myopic eyes show greater increases in axial length than nonmyopic eyes, a new retrospective longitudinal study shows. In particular, eyes with myopic choroidal neovascularization (CNV) show the greatest increases.
6 days ago
Compared with the lowest scores, the highest low-carbohydrate diet scores are associated with a 17 percent higher risk of diabetes mellitus, according to a new meta-analysis.
5 days ago
Children with sleep apnoea have significantly higher risks of developing depressive disorders than those without the sleep disorder, a new retrospective cohort study reveals.