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Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
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Tristan Manalac, Yesterday
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Thrombotic recurrence, organ damage likely in patients with primary antiphospholipid syndrome

17 Aug 2017

A large number of patients face new thrombotic events and organ damage in spite of therapy, while evolution toward connective tissue disease (CTD) is infrequent, according to a recent study.

Researchers retrospectively reviewed medical records of patients with primary antiphospholipid syndrome (PAPS) followed in six centres for ≥15 years to assess the long-term frequency of thrombotic recurrences, obstetrical complications, organ damage, severe comorbidities and evolution toward CTD in PAPS.

A total of 115 patients were analysed (mean age at diagnosis 33 years; 88 percent women) and followed between 1983 and 2014.

There were 50 patients (44 percent) who had at least a thrombotic event for a total of 75 events and an annual incidence of 3.5 percent during a median follow-up of 18 years (range, 15 to 30 years). Those with previous thrombotic history experienced more frequent thromboses (p=0.002).

Six patients (5 percent) had a catastrophic antiphospholipid syndrome. Oral anticoagulation did not appear to protect patients with thrombotic onset against recurrences (p=0.26).

Of the 87 pregnancies in 52 women, 78 percent were successful. Functional damage occurred in 29 percent of patients. Patients with a thrombotic history (p=0.004) were likely to accrue damage, which was also significantly associated with arterial events (p<0.001), especially stroke, but not with demographics, serology or treatment.

A total of 14 major bleeding episodes were recorded in 18 patients who received anticoagulants. Severe infections affected six patients (5 percent), with one fatality. Eight patients (7 percent) had a diagnosis of a solid cancer.

In total, 16 patients (14 percent) developed an autoimmune disease and 13 (11 percent) a full-blown picture of CTD, according to researchers.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.