Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
9 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 11 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Tetravalent TV003 vaccine safe, immunogenic for Flavivirus-exposed patients

21 Jul 2017
Wolbachia-infected mosquitoes have been released in Selangor.

The TV003 tetravalent dengue vaccine is well-tolerated and produces a strong antibody and immune response in patients who have previously been exposed to other Flaviviruses, a new randomized controlled trial has shown.

Investigators randomized 58 participants (median age 30 [20 to 50] years; 46 percent male) to receive either placebo (n=17) or the TV003 vaccine (n=41).

The vaccine was well-tolerated. Between the two groups, only cases of rashes were significantly more common in the vaccine group (66 vs 6 percent; p<0.001), 81 percent of which were mild and 18.5 percent were moderate.

One patient suffered from two serious adverse events: syncope 51 days after vaccination and a transient ischaemic attack 77 days after vaccination. Both were determined to be unrelated to the vaccine.

There were no significant differences in the occurrence of erythema, pain, tenderness, fevers, headaches, retro-orbital pain and myalgia (p=1.00 for all) between the groups.

In terms of serological response, one dose of the TV003 vaccine prompted an 87 percent antibody response rate to all four dengue serotypes. Viremia was achieved in 76 percent of the participants.

The second TV003 dose did not yield significant viremia or spikes in antibody titers, suggesting that one dose is enough to protect against dengue. The mean peak titers ranged from 0.86 to 1.1 log10 PFU/mL.

The tetravalent TV003 vaccine candidate was designed to protect against all four dengue serotypes. The vaccine was administered at 0.5-mL doses subcutaneously. Clinical assessments were performed every other day for the first 16 days, and on days 21, 28, 56 and 90. A second vaccine or placebo dose was administered on day 180.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
9 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 11 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.