Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Testosterone treatment increases bone density, strength in low-testosterone men

Audrey Abella
09 Mar 2017

Testosterone treatment significantly increased volumetric bone mineral density (vBMD) and estimated bone strength in older men with low testosterone levels, according to a recent study.

In this placebo-controlled, double-blind trial, 211 men (mean age, 72.3 years) with low serum testosterone concentrations were randomized to receive a daily dose of testosterone gel (n=110) or placebo (n=101) for one year, 189 of whom completed the treatment (n=104 and 85 in the testosterone and placebo arms, respectively). [JAMA Intern Med 2017;doi:10.1001/jamainternmed.2016.9539]

Compared with placebo, testosterone treatment was associated with significantly greater increases in mean lumbar spine trabecular vBMD (7.5 percent, 95 percent confidence interval [CI], 4.8–10.3 percent vs 0.8 percent, 95 percent CI, -1.9 to 3.4 percent; p<0.001) and mean estimated strength of spine trabecular bone (10.8 percent, 95 percent CI, 7.4–14.3 percent vs 2.4 percent, 95 percent CI, −1.0 to 5.7 percent; p<0.001).

Testosterone treatment also increased mean areal BMD in the lumbar spine and total hip compared with placebo (3.3 percent, 95 percent CI, 2.01–4.56 percent vs 2.1 percent, 95 percent CI, 0.87–3.36 percent; p=0.01 for lumbar spine and 1.2 percent, 95 percent CI, 0.19–2.17 percent vs 0.5 percent, 95 percent CI, -0.45 to 1.46 percent; p=0.052 for total hip).

“[The] results are unequivocal compared with prior studies of the effect of testosterone treatment on bone in older men, in spite of treatment limited to [one] year, perhaps because the mean pretreatment testosterone level was lower,” said the researchers.

The incidence of fractures during the treatment period (n=6 in each treatment arm) and subsequent follow-up (n=3 and 4 in the testosterone and placebo arms, respectively) was also a notable finding. As men’s susceptibility to fracture increases with age, a more comprehensive trial is warranted to establish the role of testosterone treatment in reducing fracture risk in this population, they added.

Osteoporosis appeared to be a significant consideration, given previous study findings showing similar results of improved vBMD and estimated bone strength with anabolic or antiresorptive agents for osteoporosis. [J Clin Endocrinol Metab 2013;98:571-580; J Bone Miner Res 2014;29:158-165] However, the inclusion of nonosteoporotic men in the current study limited the findings as the results could not be presumed for a male population with osteoporosis but not low testosterone levels, noted the researchers.

 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.