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one year ago
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Testing the efficacy of repetitive transcranial magnetic stimulation for acute depression

4 months ago
Different repetitive transcranial magnetic stimulation (rTMS) modalities have minimal differences in clinical efficacy and acceptability for acute depressive disorder, new study shows.

The systematic review and meta-analysis evaluated the response rate, acceptability and remission using different rTMS strategies for treatment of acute depression.

The analysis included 81 randomized trials that assessed rTMS modalities versus sham or another rTMS intervention. A total of 4,233 patients were included. The mean age of the subjects was 46 years and majority were women (59.1%).

Priming low-frequency, bilateral, high-frequency, low-frequency, and θ-burst rTMS were more effective than sham. Accelerated, synchronized, and deep rTMS were less effective than sham.

The rTMS modalities had similar remission response rates, except for θ-burst stimulation. Acceptability was similar for all rTMS interventions.

The most effective and acceptable rTMS strategies were priming low-frequency and bilateral methods.

The investigators concluded that the study results do not have high reliability due to lack of available trials for the different rTMS interventions except for than low-frequency, high-frequency, and bilateral methods.

It is suggested that larger RCTs should evaluate the usefulness of rTMS for treatment of major depressive disorder (MDD). Results also show that novel methods accelerated, synchronized, and deep rTMS may not be effective for MDD.
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Most Read Articles
one year ago
A study showed that borderline personality disorder (BPD) negatively affected the course of generalized anxiety disorder (GAD), social phobia and posttraumatic stress disorder (PTSD).
one year ago
New drug applications approved by US FDA as of 15 – 31 May 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
one year ago
Both the predispositions of the person who develops alcohol use disorder (AUD) and the direct results of AUD itself affect mortality in AUD.
2 years ago
A summary of the evidence on the clinical efficacy and safety profile of the novel antidepressant vortioxetine for the treatment of major depressive disorder by the US FDA.