Most Read Articles
one year ago
A longitudinal population-based study suggests that both vitamin B12 and total homocysteine concentrations may be related to accelerated aging of the brain.
3 months ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.
7 months ago
An association exists between poorer cognitive function in older people and increased variability in blood pressure (BP). This connection may signify a new modifiable risk factor for cognitive decline, suggest a recent study.
one year ago
Rivastigmine patch is safe and effective for Chinese patients with probable alzheimer's disease (AD), based on a 24-week, randomised, double-blind parallel-group study.

Testing the efficacy of repetitive transcranial magnetic stimulation for acute depression

6 months ago
Different repetitive transcranial magnetic stimulation (rTMS) modalities have minimal differences in clinical efficacy and acceptability for acute depressive disorder, new study shows.

The systematic review and meta-analysis evaluated the response rate, acceptability and remission using different rTMS strategies for treatment of acute depression.

The analysis included 81 randomized trials that assessed rTMS modalities versus sham or another rTMS intervention. A total of 4,233 patients were included. The mean age of the subjects was 46 years and majority were women (59.1%).

Priming low-frequency, bilateral, high-frequency, low-frequency, and θ-burst rTMS were more effective than sham. Accelerated, synchronized, and deep rTMS were less effective than sham.

The rTMS modalities had similar remission response rates, except for θ-burst stimulation. Acceptability was similar for all rTMS interventions.

The most effective and acceptable rTMS strategies were priming low-frequency and bilateral methods.

The investigators concluded that the study results do not have high reliability due to lack of available trials for the different rTMS interventions except for than low-frequency, high-frequency, and bilateral methods.

It is suggested that larger RCTs should evaluate the usefulness of rTMS for treatment of major depressive disorder (MDD). Results also show that novel methods accelerated, synchronized, and deep rTMS may not be effective for MDD.
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Most Read Articles
one year ago
A longitudinal population-based study suggests that both vitamin B12 and total homocysteine concentrations may be related to accelerated aging of the brain.
3 months ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.
7 months ago
An association exists between poorer cognitive function in older people and increased variability in blood pressure (BP). This connection may signify a new modifiable risk factor for cognitive decline, suggest a recent study.
one year ago
Rivastigmine patch is safe and effective for Chinese patients with probable alzheimer's disease (AD), based on a 24-week, randomised, double-blind parallel-group study.