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07 Aug 2016
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New drug applications approved by US FDA as of 16 - 30 Apr 2016 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
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Testing the efficacy of repetitive transcranial magnetic stimulation for acute depression

10 Jan 2017
Different repetitive transcranial magnetic stimulation (rTMS) modalities have minimal differences in clinical efficacy and acceptability for acute depressive disorder, new study shows.

The systematic review and meta-analysis evaluated the response rate, acceptability and remission using different rTMS strategies for treatment of acute depression.

The analysis included 81 randomized trials that assessed rTMS modalities versus sham or another rTMS intervention. A total of 4,233 patients were included. The mean age of the subjects was 46 years and majority were women (59.1%).

Priming low-frequency, bilateral, high-frequency, low-frequency, and θ-burst rTMS were more effective than sham. Accelerated, synchronized, and deep rTMS were less effective than sham.

The rTMS modalities had similar remission response rates, except for θ-burst stimulation. Acceptability was similar for all rTMS interventions.

The most effective and acceptable rTMS strategies were priming low-frequency and bilateral methods.

The investigators concluded that the study results do not have high reliability due to lack of available trials for the different rTMS interventions except for than low-frequency, high-frequency, and bilateral methods.

It is suggested that larger RCTs should evaluate the usefulness of rTMS for treatment of major depressive disorder (MDD). Results also show that novel methods accelerated, synchronized, and deep rTMS may not be effective for MDD.
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Most Read Articles
07 Aug 2016
A study suggests that the level of raphe nuclei (RN) serotonin1A binding potential predicts future suicidal ideation and the lethality of suicidal behavior.
30 Apr 2016
New drug applications approved by US FDA as of 16 - 30 Apr 2016 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
08 Sep 2016
Individuals hospitalized with infection may be at risk for death by suicide, a study shows.
02 Dec 2015
Patients with chronic fatigue syndrome may benefit from cognitive behavioural therapy (CBT) or graded exercise therapy (GET), a long-term follow up from the PACE trial has shown.