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Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Terlipressin may reverse HRS in patients with systemic inflammatory response syndrome

06 Feb 2017

Terlipressin may produce more favourable outcomes in patients with systemic inflammatory response syndrome (SIRS), improving renal function and reversing hepatorenal syndrome (HRS) compared with albumin plus placebo, a retrospective study suggests.

Researchers reviewed the medical records of 198 patients with HRS type 1 who participated in a trial evaluating the effects of terlipressin (1 mg every 6 hours) vs placebo with concomitant albumin. Two patient groups were identified, including those with two or more criteria for SIRS and those with with less than two criteria for SIRS (controls).

The main endpoints were HRS reversal (serum creatinine level decreasing to ≤1.5 mg/dL), confirmed HRS reversal (two serum creatinine levels ≤1.5 mg/dL; ≥48 hours apart) and survival for 90 days after treatment.

The two patients groups showed similar baseline characteristics, with the exception of SIRS patients having slightly higher white blood cell counts and heart rates and slightly lower serum bicarbonate levels compared with controls.

HRS reversal occurred in 42.9 percent of SIRS patients who received terlipressin (12/28) vs 6.7 percent of those who received placebo (2/30; p=0.0018).

The proportion of patients with confirmed HRS reversal was 32.1 percent in the terlipressin group vs 3.3 percent in the placebo group (p=0.0048). Those who survived for 90 days without a transplant was 46.4 vs 23.3 percent, respectively, (p=0.076).

HRS is characterized by portal hypertension with impaired kidney perfusion by vasoconstrictor endogenous mediators in patients with liver cirrhosis, acute liver failure or alcoholic hepatitis. While the condition may be reversed, HRS poses a life-threatening risk, requiring prompt diagnosis and rapid treatment. [Gastroenterol Res Pract 2015;457613]

Type I HRS is particularly associated with poor prognosis. This subtype develops rapidly, as may be indicated by the doubling of the serum creatinine concentration within 2 weeks. Patients with this HRS type have a mortality of 50 percent after 2 weeks of diagnosis, increasing to 100 percent within months.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.