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Temporal low-frequency BOLD signals altered in adult moyamoya disease

17 Aug 2017
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Adult moyamoya disease (MMD) patients exhibit changes in the temporal correlations of low-frequency blood-oxygen-level-dependent (BOLD) signals in resting state-functional magnetic resonance imaging (rs-fMRI), a new study has shown.

Voxel-level analysis of 31 adult MMD patients (mean age 41.9±10.8 years) and 25 healthy controls (mean age 38.8±8.1 years) showed that temporal correlations of low-frequency BOLD signals were altered in patients, particularly in the right pre- and postcentral gyri, left insular cortex, bilateral anterior cingulate gyrus, right middle frontal gyrus, left precentral gyrus and bilateral precuneus.

Additionally, MMD patients had lower connectivity between the left insula and anterior segment of the cingulate gyrus, precentral gyrus, opercular regions and right insular cortex. Connectivity between the left precuneus and right supramarginal gyrus was also decreased in MMD patients.

Connectivity between the right and left precentral gyrus, and right and left middle frontal gyrus was also reduced in MMD patients.

Connections between the left hippocampus and right inferior occipital regions were significantly positively correlated with the perceptual organization (PO; p=0.0212), working memory (WM; p=0.0004) and processing speed (PS; p=0.0018) measures of cognitive performance.

No other connection between regions of interest was significantly correlated with more than one of the aforementioned measures of cognitive performance.

All study participants were diagnosed with idiopathic MMD. Those with histories of intracranial haemorrhage, previous revascularization surgeries and cortical infarctions >3 cm large were excluded. Rs-FMRI was used to measure connectivity between brain regions of interest.

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