Most Read Articles
05 Aug 2017
Discontinuation of antihypertensive drugs appears to have a detrimental effect, with a recent study reporting that the risk of acute myocardial infarction (AMI) substantially increases after more than 90 days of discontinuation.
Roshini Claire Anthony, 15 hours ago

Once-weekly doses of the glucagon-like peptide-1 receptor agonist exenatide plus insulin glargine improved glucose control and weight loss in patients whose type 2 diabetes (T2D) was uncontrolled on basal insulin and metformin, according to findings from the DURATION-7* trial.

03 Aug 2017
Cetuximab and docetaxel is safe and effective during postoperative radiotherapy for high-risk head and neck cancer patients who cannot receive cisplatin, a new study has found.
08 Sep 2017
Prediagnostic statin exposure appears to be associated with a significant reduction in breast cancer-specific mortality, with the survival benefit being more pronounced in women with oestrogen receptor (ER)-positive tumours, according to a study.

Tamoxifen use in breast cancer not linked to acute pancreatitis

17 Mar 2017
There are studies ongoing to grow human organs in pigs to help address lack of organs for transplants.

The use of tamoxifen in breast cancer patients is not associated with the incidence of acute pancreatitis (AP), a new study shows.

The population-based cohort study used data from the National Health Insurance Research Database of Taiwan. New-onset breast cancer patients at least 20 years of age were included. Those with histories of pancreatic cancer and acute and chronic pancreatitis were excluded.

The accumulated defined daily dose (DDD) of tamoxifen prescribed during the follow-up periodwas calculated. Prescription information was calculated yearly after the index date to account for changes in drug use over time.

Before propensity score matching, 22,005 patients (mean age53.4 years)did not receive tamoxifen while 40,484 did (mean age 51.4 years). Asthma (p=0.01) and hyperlipidaemia (p<0.001) were more common in nonusers while fluorouracil use was more common in tamoxifen users (p<0.001). Differences disappeared after propensity score matching.

Alcohol-related diseases (adjusted hazard ratio [aHR], 1.56; 95 percent CI, 0.50 to 4.88), despite being known to cause chronic and acute pancreatitis, were not associated with AP after controlling for age. Similarly, hepatitis B (aHR, 1.15; 0.62 to 2.10) and hepatitis C (aHR, 1.28; 0.63 to 2.61) virus infections were also not associated with AP.

On the other hand, diabetes mellitus (aHR, 1.63; 1.23 to 2.61) and gallstones (aHR, 3.19; 2.33 to 4.35) correlated with an increased risk of AP after controlling for age.

After adjustment for age, comorbidities and medications, the risk of AP was not significant between tamoxifen users and nonusers (aHR, 0.94; 0.74 to 1.19) in the nonmatching cohorts. No dose–response trend existed between tamoxifen use and the risk of AP (aHR, 0.98; 0.96 to 1.00).

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Most Read Articles
05 Aug 2017
Discontinuation of antihypertensive drugs appears to have a detrimental effect, with a recent study reporting that the risk of acute myocardial infarction (AMI) substantially increases after more than 90 days of discontinuation.
Roshini Claire Anthony, 15 hours ago

Once-weekly doses of the glucagon-like peptide-1 receptor agonist exenatide plus insulin glargine improved glucose control and weight loss in patients whose type 2 diabetes (T2D) was uncontrolled on basal insulin and metformin, according to findings from the DURATION-7* trial.

03 Aug 2017
Cetuximab and docetaxel is safe and effective during postoperative radiotherapy for high-risk head and neck cancer patients who cannot receive cisplatin, a new study has found.
08 Sep 2017
Prediagnostic statin exposure appears to be associated with a significant reduction in breast cancer-specific mortality, with the survival benefit being more pronounced in women with oestrogen receptor (ER)-positive tumours, according to a study.