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T786C polymorphism in endothelial nitric oxide synthase gene tied to in-stent restenosis after drug-eluting stent

02 Feb 2017

The T786C polymorphism in the endothelial nitric oxide synthase gene is associated with in-stent restenosis in a Chinese Han population treated with drug-eluting stent, a new study reports.

Researchers recruited 425 patients diagnosed with coronary artery disease. For inclusion, participants had to have successfully undergone revascularization in the native coronary arteries through drug-eluting stent.

To identify the six putative single-nucleotide polymorphisms, genotyping was performed on the endothelial nitric oxide synthase gene, the angiotensin II type 1 receptor gene, the angiotensin converting enzyme gene, the vascular endothelial growth factor gene and the transforming growth factor beta gene.

During the follow-up period, quantitative coronary angiography was performed on the patients to detect in-stent restenosis. Pertinent and relevant associations were evaluated using logistic regression models.

Of all the participants, 54 (12.7 percent) were found to develop in-stent restenosis during the course of the study. Interestingly, this group showed significantly increased frequency of the C allele of the T786C polymorphism in the endothelial nitric oxide synthase gene compared with the group without in-stent restenosis (p<0.01).

The frequencies of other genotypes were not significantly different from each other.

After adjusting for confounders, the multivariable analysis showed that an increased risk of in-stent restenosis was associated with both the additive (odds ratio [OR], 1.870; 95 percent CI, 1.079 to 3.240; p=0.03) and dominant (OR, 2.045; 1.056 to 3.958; p=0.03) models of the T786C polymorphism.

The findings show that in-stent restenosis is associated with the T786C polymorphism in the endothelial nitric oxide synthase gene in patients who have received drug-eluting stent.

The authors recommend employing genotyping programmes to better identify those at high risk of in-stent restenosis following drug-eluting stent implantation.

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Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.