Most Read Articles
Roshini Claire Anthony, one year ago

Individuals with carotid artery stenosis have a similar incidence of periprocedural stroke, myocardial infarction (MI), and death, or ipsilateral stroke 10 years post-procedure regardless of whether they undergo endarterectomy or stenting, according to recent results from the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST).

2 years ago
A case control study indicated the reduction in risk for non-fatal acute myocardial infarction (AMI) in allopurinol users.
Christina Lau, 3 years ago

The novel oral anticoagulant (OAC) dabigatran is better than warfarin for stroke prevention in Asian patients with atrial fibrillation (AF), according to a new analysis that included patients from Hong Kong.

Tristan Manalac, 2 months ago
Sodium content in the skin is significantly related to left ventricular mass in patients with chronic kidney disease (CKD), reports a new study.

T786C polymorphism in endothelial nitric oxide synthase gene tied to in-stent restenosis after drug-eluting stent

5 months ago

The T786C polymorphism in the endothelial nitric oxide synthase gene is associated with in-stent restenosis in a Chinese Han population treated with drug-eluting stent, a new study reports.

Researchers recruited 425 patients diagnosed with coronary artery disease. For inclusion, participants had to have successfully undergone revascularization in the native coronary arteries through drug-eluting stent.

To identify the six putative single-nucleotide polymorphisms, genotyping was performed on the endothelial nitric oxide synthase gene, the angiotensin II type 1 receptor gene, the angiotensin converting enzyme gene, the vascular endothelial growth factor gene and the transforming growth factor beta gene.

During the follow-up period, quantitative coronary angiography was performed on the patients to detect in-stent restenosis. Pertinent and relevant associations were evaluated using logistic regression models.

Of all the participants, 54 (12.7 percent) were found to develop in-stent restenosis during the course of the study. Interestingly, this group showed significantly increased frequency of the C allele of the T786C polymorphism in the endothelial nitric oxide synthase gene compared with the group without in-stent restenosis (p<0.01).

The frequencies of other genotypes were not significantly different from each other.

After adjusting for confounders, the multivariable analysis showed that an increased risk of in-stent restenosis was associated with both the additive (odds ratio [OR], 1.870; 95 percent CI, 1.079 to 3.240; p=0.03) and dominant (OR, 2.045; 1.056 to 3.958; p=0.03) models of the T786C polymorphism.

The findings show that in-stent restenosis is associated with the T786C polymorphism in the endothelial nitric oxide synthase gene in patients who have received drug-eluting stent.

The authors recommend employing genotyping programmes to better identify those at high risk of in-stent restenosis following drug-eluting stent implantation.

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Most Read Articles
Roshini Claire Anthony, one year ago

Individuals with carotid artery stenosis have a similar incidence of periprocedural stroke, myocardial infarction (MI), and death, or ipsilateral stroke 10 years post-procedure regardless of whether they undergo endarterectomy or stenting, according to recent results from the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST).

2 years ago
A case control study indicated the reduction in risk for non-fatal acute myocardial infarction (AMI) in allopurinol users.
Christina Lau, 3 years ago

The novel oral anticoagulant (OAC) dabigatran is better than warfarin for stroke prevention in Asian patients with atrial fibrillation (AF), according to a new analysis that included patients from Hong Kong.

Tristan Manalac, 2 months ago
Sodium content in the skin is significantly related to left ventricular mass in patients with chronic kidney disease (CKD), reports a new study.