T786C polymorphism in endothelial nitric oxide synthase gene tied to in-stent restenosis after drug-eluting stent
The T786C polymorphism in the endothelial nitric oxide synthase gene is associated with in-stent restenosis in a Chinese Han population treated with drug-eluting stent, a new study reports.
Researchers recruited 425 patients diagnosed with coronary artery disease. For inclusion, participants had to have successfully undergone revascularization in the native coronary arteries through drug-eluting stent.
To identify the six putative single-nucleotide polymorphisms, genotyping was performed on the endothelial nitric oxide synthase gene, the angiotensin II type 1 receptor gene, the angiotensin converting enzyme gene, the vascular endothelial growth factor gene and the transforming growth factor beta gene.
During the follow-up period, quantitative coronary angiography was performed on the patients to detect in-stent restenosis. Pertinent and relevant associations were evaluated using logistic regression models.
Of all the participants, 54 (12.7 percent) were found to develop in-stent restenosis during the course of the study. Interestingly, this group showed significantly increased frequency of the C allele of the T786C polymorphism in the endothelial nitric oxide synthase gene compared with the group without in-stent restenosis (p<0.01).
The frequencies of other genotypes were not significantly different from each other.
After adjusting for confounders, the multivariable analysis showed that an increased risk of in-stent restenosis was associated with both the additive (odds ratio [OR], 1.870; 95 percent CI, 1.079 to 3.240; p=0.03) and dominant (OR, 2.045; 1.056 to 3.958; p=0.03) models of the T786C polymorphism.
The findings show that in-stent restenosis is associated with the T786C polymorphism in the endothelial nitric oxide synthase gene in patients who have received drug-eluting stent.
The authors recommend employing genotyping programmes to better identify those at high risk of in-stent restenosis following drug-eluting stent implantation.