Most Read Articles
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 months ago

Individuals with a history of migraine may be at a higher risk for ischaemic stroke within 1 month postsurgery, a recent study found.

Kathlin Ambrose, one year ago

Doctors uncertain on which cardiovascular (CV) risk calculator to use may consider opting for the Framingham General CV Disease risk score as studies have been performed in the country to validate it, says an expert.

one year ago
New drug applications approved by US FDA as of 16 - 31 Oct 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

T786C polymorphism in endothelial nitric oxide synthase gene tied to in-stent restenosis after drug-eluting stent

3 months ago

The T786C polymorphism in the endothelial nitric oxide synthase gene is associated with in-stent restenosis in a Chinese Han population treated with drug-eluting stent, a new study reports.

Researchers recruited 425 patients diagnosed with coronary artery disease. For inclusion, participants had to have successfully undergone revascularization in the native coronary arteries through drug-eluting stent.

To identify the six putative single-nucleotide polymorphisms, genotyping was performed on the endothelial nitric oxide synthase gene, the angiotensin II type 1 receptor gene, the angiotensin converting enzyme gene, the vascular endothelial growth factor gene and the transforming growth factor beta gene.

During the follow-up period, quantitative coronary angiography was performed on the patients to detect in-stent restenosis. Pertinent and relevant associations were evaluated using logistic regression models.

Of all the participants, 54 (12.7 percent) were found to develop in-stent restenosis during the course of the study. Interestingly, this group showed significantly increased frequency of the C allele of the T786C polymorphism in the endothelial nitric oxide synthase gene compared with the group without in-stent restenosis (p<0.01).

The frequencies of other genotypes were not significantly different from each other.

After adjusting for confounders, the multivariable analysis showed that an increased risk of in-stent restenosis was associated with both the additive (odds ratio [OR], 1.870; 95 percent CI, 1.079 to 3.240; p=0.03) and dominant (OR, 2.045; 1.056 to 3.958; p=0.03) models of the T786C polymorphism.

The findings show that in-stent restenosis is associated with the T786C polymorphism in the endothelial nitric oxide synthase gene in patients who have received drug-eluting stent.

The authors recommend employing genotyping programmes to better identify those at high risk of in-stent restenosis following drug-eluting stent implantation.

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Most Read Articles
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 months ago

Individuals with a history of migraine may be at a higher risk for ischaemic stroke within 1 month postsurgery, a recent study found.

Kathlin Ambrose, one year ago

Doctors uncertain on which cardiovascular (CV) risk calculator to use may consider opting for the Framingham General CV Disease risk score as studies have been performed in the country to validate it, says an expert.

one year ago
New drug applications approved by US FDA as of 16 - 31 Oct 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.