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Denosumab brings greater gains in spine and hip bone mineral density (BMD) than risedronate in glucocorticoid-treated patients at risk of osteoporotic fracture, according to results of a phase III study presented at the European League Against Rheumatism (EULAR) Annual Congress 2017 in Madrid, Spain.

T2D ups mortality after coronary artery bypass surgery

14 Jul 2017

Type 2 diabetes mellitus (T2DM) patients have a significantly higher mortality rate following coronary artery bypass surgery (CABG) compared with those without T2DM, according to a new meta-analysis.

A meta-analysis of 11 studies (n=12,965 patients) that investigated mortality after CABG in human participants with and without T2DM found that mortality was significantly higher in T2DM patients (odds ratio [OR], 1.54; 95 percent CI, 1.37 to 1.72; p<0.00001) over a follow up of 1 to 15 years.

Results remained consistent even when considering follow-up periods of 5 to 15 (OR, 1.53; 1.36 to 1.72; p<0.00001) and 7 to 15 (OR, 1.53; 1.26 to 1.87; p<0.0001) years.

Subtype analysis with respect to type of death showed that both all-cause mortality (OR, 1.34; 1.12 to 1.60; p=0.001) and cardiac death (OR, 1.62; 1.31 to 2.00; p<0.00001) was significantly higher in T2DM patients.

Further analysis showed that short-term (1 to 5 years; OR, 1.65; 1.07 to 2.54; p=0.02), middle-term (5 to 7 years; OR, 1.53; 1.32 to 1.76; p<0.00001) and long-term mortality (7 to 15 years; OR, 1.53; 1.26 to 1.87; p<0.0001) were all significantly greater in T2DM patients.

In contrast, other adverse cardiovascular outcomes, such as myocardial infarction (OR, 1.15; 0.81 to 1.64; p=0.44), repeated revascularization (OR, 1.09; 0.88 to 1.36; p=0.43) and stroke (OR, 1.69; 0.93 to 3.07; p=0.08) were not significantly more common in T2DM patients.

The meta-analysis was performed on six randomized controlled trials (RCTs) and five observational studies retrieved from Medline, the Cochrane Library and Embase. Those with follow-up periods of <1 year, that did not report on mortality or that did not include control were excluded.

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Most Read Articles
01 May 2017
Body mass index (BMI), body fat and waist circumference are highly correlated, and all show an association with aggressive prostate cancer, according to a study.
21 Jun 2017
Podcast: Dr Steven Marso speaks about the cardiovascular safety of insulin degludec vs insulin glargine in patients with type 2 diabetes with high cardiovascular risk.
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Adults with type 1 diabetes (T1D) who are prescribed metformin experience reductions in atherosclerosis progression and LDL cholesterol, according to results of the REMOVAL* study. However, the impact of metformin on glycaemic control in these patients is limited.

Christina Lau, 21 Jun 2017

Denosumab brings greater gains in spine and hip bone mineral density (BMD) than risedronate in glucocorticoid-treated patients at risk of osteoporotic fracture, according to results of a phase III study presented at the European League Against Rheumatism (EULAR) Annual Congress 2017 in Madrid, Spain.