Most Read Articles
one year ago
Painful diabetic neuropathy (PDN) is one of the many complications of diabetes. At the Diabetes Asia 2015 Conference, renowned speaker Dr Mary Cardosa gave an overview on PDN and the approaches to managing this condition.
one year ago
Sevelamer increases serum magnesium levels and reduces risk of hypomagnesemia in end-stage renal disease patients requiring haemodialysis, according to a study.
one year ago
Pioglitazone reduces risk for stroke or myocardial infaction (MI) in patients with history of ischaemic stroke or transient ischaemic attack (TIA), based on a multicentre, double-blind trial.
one year ago
A study revealed differences in the key pathophysiological features in the diabetic heart of type 1 and type 2 diabetes mellitus (DM) mouse models.

T2D ups mortality after coronary artery bypass surgery

7 days ago

Type 2 diabetes mellitus (T2DM) patients have a significantly higher mortality rate following coronary artery bypass surgery (CABG) compared with those without T2DM, according to a new meta-analysis.

A meta-analysis of 11 studies (n=12,965 patients) that investigated mortality after CABG in human participants with and without T2DM found that mortality was significantly higher in T2DM patients (odds ratio [OR], 1.54; 95 percent CI, 1.37 to 1.72; p<0.00001) over a follow up of 1 to 15 years.

Results remained consistent even when considering follow-up periods of 5 to 15 (OR, 1.53; 1.36 to 1.72; p<0.00001) and 7 to 15 (OR, 1.53; 1.26 to 1.87; p<0.0001) years.

Subtype analysis with respect to type of death showed that both all-cause mortality (OR, 1.34; 1.12 to 1.60; p=0.001) and cardiac death (OR, 1.62; 1.31 to 2.00; p<0.00001) was significantly higher in T2DM patients.

Further analysis showed that short-term (1 to 5 years; OR, 1.65; 1.07 to 2.54; p=0.02), middle-term (5 to 7 years; OR, 1.53; 1.32 to 1.76; p<0.00001) and long-term mortality (7 to 15 years; OR, 1.53; 1.26 to 1.87; p<0.0001) were all significantly greater in T2DM patients.

In contrast, other adverse cardiovascular outcomes, such as myocardial infarction (OR, 1.15; 0.81 to 1.64; p=0.44), repeated revascularization (OR, 1.09; 0.88 to 1.36; p=0.43) and stroke (OR, 1.69; 0.93 to 3.07; p=0.08) were not significantly more common in T2DM patients.

The meta-analysis was performed on six randomized controlled trials (RCTs) and five observational studies retrieved from Medline, the Cochrane Library and Embase. Those with follow-up periods of <1 year, that did not report on mortality or that did not include control were excluded.

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Most Read Articles
one year ago
Painful diabetic neuropathy (PDN) is one of the many complications of diabetes. At the Diabetes Asia 2015 Conference, renowned speaker Dr Mary Cardosa gave an overview on PDN and the approaches to managing this condition.
one year ago
Sevelamer increases serum magnesium levels and reduces risk of hypomagnesemia in end-stage renal disease patients requiring haemodialysis, according to a study.
one year ago
Pioglitazone reduces risk for stroke or myocardial infaction (MI) in patients with history of ischaemic stroke or transient ischaemic attack (TIA), based on a multicentre, double-blind trial.
one year ago
A study revealed differences in the key pathophysiological features in the diabetic heart of type 1 and type 2 diabetes mellitus (DM) mouse models.