Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.

Syndromes affecting bowel health in cancer survivors may occur as late effects of pelvic radiotherapy

09 Feb 2017

Five symptoms that affect bowel health may be attributed to late effects of radiotherapy, new study reports. Studying the underlying causes of these symptoms should simplify the prevention and treatment of a variety of other downstream symptoms.

A total of 623 survivors who had received external pelvic radiotherapy for gynaecological malignancies between 1991 and 2003 were recruited for the study. Simultaneously, 344 eligible and matched women were included as controls.

Survivors were then followed up for at least 2 and at most 15 years after radiotherapy. Both patients and controls completed questionnaires designed to extract information and symptoms regarding bowel health.

As per the parallel analysis, six factors were found to optimally explain the correlation structure among the symptoms. Of these, only five were statistically different between controls and patients.

The five factors were urgency syndrome, excessive gas discharge, blood discharge, leakage syndrome and excessive mucus discharge. The sixth factor, constipation, was comparable between controls and patients.

When designated as radiation-induced syndromes reflecting survivorship diseases, the five factors cumulatively accounted for 42 percent of the variance of all the symptoms examined in the study.

Of the gynaecological cancer survivors, 30 percent had urgency syndrome, 26 percent had leakage syndrome, 15 percent had excessive gas discharge, 16 percent had excessive mucus discharge, and 10 percent had blood discharge.

The findings show that the five factors may impact on bowel health in gynaecological cancer survivors who have undergone radiotherapy. Further studies on these factors, instead of on the 28 bowel symptoms, may prove more efficient at identifying a viable prevention and treatment technique.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.