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Synbiotics effective treatment for atopic dermatitis

27 May 2016

Synbiotics—mixtures of prebiotics and probiotics—are effective in the treatment of atopic dermatitis (AD), particularly if they contain mixed strains of bacteria and if they are given to children aged 1 year or older, according to a recent meta-analysis.

Researchers searched the PubMed/MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and CAB Abstracts Archive databases from inception to October 15, 2015 for all randomized clinical trials of synbiotics for the prevention and/or treatment of AD published in any language.

A total of six treatment studies that collectively included 369 children (age range 0 months to 14 years) and two prevention studies involving 1,320 children (age range <3 days to 6 months) were identified. In the six treatment studies, the overall pooled change in the Severity Scoring of Atopic Dermatitis index after 8 weeks of synbiotic treatment was -6.56 (95 percent confidence interval [CI], -11.43 to -1.68; p=0.008).

However, subgroup analysis revealed that the beneficial effect was only significant if mixed strains of bacteria were used and when the synbiotic was administered to children aged 1 year or older. Analysis of data from the prevention studies revealed that compared with placebo, synbiotic recipients had a pooled relative risk of AD of 0.44 (95 percent CI, 0.11–1.83; p=0.26). 

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Most Read Articles
19 Apr 2017
No association exists between early colonoscopy and reduced rebleeding, length of stay (LOS) or surgery in patients with severe lower gastrointestinal bleeding (LGIB), according to a new study. However, early colonoscopy correlates with a higher rate of source localization and endoscopic intervention.
07 Apr 2017
Use of thiopurine for inflammatory bowel disease (IBD) during pregnancy appears to neither pose an increased risk of spontaneous abortions or adverse birth outcomes nor negatively affect health outcomes of infants 1 year after birth, a study suggests.
20 Apr 2017
Patients with Sjögren’s syndrome (SS) appear to manifest symptoms such as dysphagia, with swallowing dysfunction substantially reducing the patient quality of life, a study has shown.
12 Mar 2017
A novel scoring system developed to evaluate early dysphagia after anterior cervical spine surgery (ACSS) shows body mass index, operative time and dC2 to C7 angle to be strongly associated with developing the symptom, as reported in a new study.