Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Supplemental oxygen provides no beneficial effect on 1-year mortality

30 Sep 2017

Routine use of supplemental oxygen does not appear to cut 1-year all-cause mortality in patients with suspected myocardial infarction (MI) but who do not have hypoxaemia, a study has shown.

A total of 6,629 patients with suspected MI and an oxygen saturation of ≥90 percent were randomized to receive either supplemental oxygen (6 litres/minute for 6 to 12 hours, delivered through an open face mask) or ambient air.

The primary outcome was death from any cause within 365 days after randomization. Secondary endpoints included death from any cause within 30 days after randomization, rehospitalization with MI, rehospitalization with heart failure, cardiovascular death, as well as composites of these endpoints, assessed at 30 and 365 days.

Median duration of oxygen therapy was 11.6 hours. At the end of the treatment period, median oxygen saturation was 99 percent in the oxygen therapy arm vs 97 percent in the ambient air arm (p<0.001). Hypoxaemia occurred with greater frequency among patients given ambient air than among those who received supplemental oxygen (62 vs 254 patients; p<0.001). The median of the highest troponin level observed during hospitalization was 946.5 ng/litre in the oxygen arm vs 983.0 ng/litre in the ambient-air arm.

In Cox proportional hazards model, the primary outcome of death from any cause within 1 year of randomization did not significantly differ between the oxygen and ambient-air arms (5.0 vs 5.1 percent, respectively; hazard ratio [HR], 0.97; 95 percent CI, 0.79 to 1.21; p=0.80).

Likewise, the number of patients who were rehospitalized for MI within 1 year was similar between the two treatment arms (3.8 vs 3.3 percent; HR, 1.13; 0.88 to 1.46; P=0.33). The results were consistent across all predefined subgroups, including infarction type, sex, age, smoking status and presence of diabetes, among others.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.