Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

Sucralose exposure common in healthy young adults

20 Apr 2017

Instructions to avoid low-calorie sweeteners (LCSs) are ineffective, according to a study, adding that nondietary sources such as personal care products may significantly contribute to overall exposure.

Researchers enrolled a total of 18 healthy “nonconsumers” (<1 food or beverage with LCSs/mo; aged 18 to 35 years) in a 2-week trial that assessed the effects of LCSs on the gut microbiota and consisted of three visits.

Participants were advised extensively about avoiding LCSs at baseline. After the run-in, they were randomized to consume diet soda containing sucralose or carbonated water (control) three times per day for 1 week. Participants kept food diaries throughout the study, and a spot urine sample was taken at each visit.

“Despite the selection of healthy volunteers with minimal reported LCS consumption, more than one-third were exposed to sucralose at baseline and/or before randomization, and nearly half were exposed after assignment to the control,” researchers said.

There were eight participants who had sucralose in their urine (29.9 to 239.0 ng/mL; mean 111.4 ng/mL) at baseline. After the run-in, sucralose was detected in eight individuals, two of whom did not have detectable sucralose at baseline (25.0 to 1,062.0 ng/mL; mean 191.7 ng/mL). Only one participant reported consuming an LCS-containing food prior to her visit.

After the intervention, sucralose was found in three individuals randomized to receive carbonated water (26 to 121 ng/mL; mean 60.7 ng/mL).

LCSs are found in many foods and beverages, but consumers may not be aware of their presence. Also, the role of LCSs in appetite, weight and health remains controversial, according to researchers.

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Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.