Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
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Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.

Studies on effects of e-cigarettes on smoking cessation unreliable

28 Feb 2017
The Hong Kong government has insisted a cigarette packaging reform is vital to discourage smoking.

More studies of good quality are needed to determine the impacts of electronic nicotine delivery systems or electronic non-nicotine delivery systems on cessation of smoking, a new meta-analysis recommends. The current existing literature is not of high enough quality or certainty to yield meaningful conclusions.

Studies published in the Cochrane Central Register of Controlled Trials, Embase, Medline, Cinahl, PsychInfo and Web of Science were screened for randomized controlled trials and prospective cohort studies that investigated electronic nicotine or non-nicotine delivery systems.

Those that had a sample of smokers, compared the interventions to no cessation aids and alternative cessation aids were included. Outcomes of the studies were smoking cessation, at least 50 percent reduction in cigarette use and adverse events.

After applying the inclusion and exclusion criteria, only three randomized controlled trials corresponding to 1,007 individuals, and 9 prospective cohort studies corresponding to 13,115 individuals were found to be eligible for analysis.

Analysis of two randomized controlled trials showed that using electronic nicotine delivery systems may result in greater smoking cessation compared to electronic non-nicotine delivery systems (risk ratio [RR], 2.03; 95 percent CI, 0.94 to 4.38; p=0.07).

On the other hand, analysis of eight cohort studies reported no significant improvements in smoking cessation when electronic nicotine delivery systems were employed compared to no such system (odds ratio [OR], 0.74; 0.55 to 1.00; p=0.051).

In the analysis of both types of studies, confidence in the evidence was rated as low because of risk of bias and imprecise data, both of which were attributed to lack of blinding, missing outcome data and imprecision in assessment.

Sensitivity analyses in both randomized controlled trials and cohort studies showed inconsistencies with the findings from the primary synthesised analyses.

The results of the meta-analysis thus show that existing literature on using either electronic nicotine or non-nicotine delivery systems for smoking cessation is insufficient and of not high enough quality to draw any meaningful conclusions. 

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Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.