Structured weight-loss programme yields therapeutic weight reductions
Structured weight-loss programmes incorporating meal replacements and behavioural support appear to be an effective strategy for reducing weight in overweight or obese adults, including those with diabetes mellitus 2 (DM2) or prediabetes, a study has shown.
The study included 816 obese or overweight adults, among whom 125 had self-reported diabetes/high blood sugar (D/HBS; mean age 56.3 years; 59.2 percent female). Demographic, weight, body composition, anthropometric, pulse and blood pressure data were evaluated. Mann–Whitney U-tests and mixed model regression were used to analyse differences between cohorts by D/HBS status.
Compared with controls (non-D/HBS), individuals in the D/HBS cohort were more likely to be male (40.8 vs 25.6 percent), have a higher BMI (39.0 vs 36.3 kg m−2) and be older (56 vs 48 years). Among those who persisted with their weight-loss programme, controls lost significantly more weight than individuals with D/HBS at week 4 (5.6 vs 5.0 kg of baseline weight; p=0.005) and week 12 (11.1 vs 9.9 percent; p=0.027), whereas the observed reduction in weight at week 24 did not differ (15.7 vs 13.9 percent).
In a mixed model regression adjusting for baseline weight, gender and meal plan, and an intention-to-treat analysis, no significant differences in weight loss were observed at all time points.
Likewise, similar proportions of individuals in both the control and D/HBS groups lost ≥5 percent of their baseline weight (78 vs 74 percent, respectively), ≥10 percent (49 vs 46 percent, respectively) and ≥20 percent (11 percent for both groups). A noticeable number also had weight losses of ≥25 percent (5 percent in controls and 3 percent in the D/HBS group).
The present data reinforce the findings of the Look AHEAD study, as well as of other similar studies, which demonstrated that individuals with DM2 can lose therapeutic amounts of weight with an intensive lifestyle intervention, researchers said. [Diabetes Care 2007;30:1374–1383]