Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Stool transplant most effective when delivered via lower gastrointestinal route

21 Jan 2017

Foecal microbiota transplantation (FMT) done through the lower gastrointestinal (LGI) delivery route appears to be the most effective way for the prevention of recurrence/relapse of Clostridium difficile infection (CDI), suggests a study.

“FMT has been proven to be a safe and highly effective therapeutic option for CDI,” said researchers. “Delivery … could be via the UGI (upper gastrointestinal) or LGI routes, [but] it is unclear as to which route provides better clinical outcome.”

To determine which delivery route of FMT is the most effective for refractory or recurrent/relapsing CDI, researchers systematically searched for studies that reported the use of FMT for CDI treatment. They obtained individual patient data, including demographic (age and sex) and clinical (route of FMT delivery, CDI outcome after FMT and follow-up time) information.

To evaluate clinical failure after FMT by the delivery route, Kaplan-Meier cumulative hazard curves and Cox proportional hazard models were used.

Of the 305 participants analysed, 208 were treated with FMT via the LGI route and 97 via the UGI route.

The risk of clinical failure at 30 and 90 days was 5.6 and 17.9 percent in the UGI delivery route group compared with 4.8 and 8.5 percent in the LGI group, respectively. Based on a time-varying analysis, UGI delivery had a threefold increase in hazard of clinical failure (hazard ratio, 3.43; 95 percent CI, 1.32 to 8.93) in the period after 30 days.

Researchers suggested that a randomized controlled trial be conducted to determine whether FMT delivered via the LGI route is indeed better than that delivered via the UGI route.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.