Most Read Articles
one year ago
Entecavir yields more favourable survival outcomes than lamivudine treatment in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), as shown in a retrospective cohort study.
one year ago
Saccharomyces boulardii has favourable safety and efficacy in the treatment of children aged 3 months to 5 years with acute rotavirus diarrhoea, based on a double-blind, randomised controlled trial from a developing country.
Saras Ramiya, 6 years ago

Patients with symptoms of peptic ulcer and who are at high risk of gastric cancer should be further examined for early detection of disease, says a leading gastrointestinal surgeon.

one year ago
While the type 1 cholecystokinin (CCK) receptor (CCK1R) malfunctions as a result of increased gallbladder cholesterol, ursodeoxycholic acid (UDCA) changes its conformation and prevents cholesterol gallstone formation.

Stool transplant most effective when delivered via lower gastrointestinal route

6 months ago

Foecal microbiota transplantation (FMT) done through the lower gastrointestinal (LGI) delivery route appears to be the most effective way for the prevention of recurrence/relapse of Clostridium difficile infection (CDI), suggests a study.

“FMT has been proven to be a safe and highly effective therapeutic option for CDI,” said researchers. “Delivery … could be via the UGI (upper gastrointestinal) or LGI routes, [but] it is unclear as to which route provides better clinical outcome.”

To determine which delivery route of FMT is the most effective for refractory or recurrent/relapsing CDI, researchers systematically searched for studies that reported the use of FMT for CDI treatment. They obtained individual patient data, including demographic (age and sex) and clinical (route of FMT delivery, CDI outcome after FMT and follow-up time) information.

To evaluate clinical failure after FMT by the delivery route, Kaplan-Meier cumulative hazard curves and Cox proportional hazard models were used.

Of the 305 participants analysed, 208 were treated with FMT via the LGI route and 97 via the UGI route.

The risk of clinical failure at 30 and 90 days was 5.6 and 17.9 percent in the UGI delivery route group compared with 4.8 and 8.5 percent in the LGI group, respectively. Based on a time-varying analysis, UGI delivery had a threefold increase in hazard of clinical failure (hazard ratio, 3.43; 95 percent CI, 1.32 to 8.93) in the period after 30 days.

Researchers suggested that a randomized controlled trial be conducted to determine whether FMT delivered via the LGI route is indeed better than that delivered via the UGI route.

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Most Read Articles
one year ago
Entecavir yields more favourable survival outcomes than lamivudine treatment in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), as shown in a retrospective cohort study.
one year ago
Saccharomyces boulardii has favourable safety and efficacy in the treatment of children aged 3 months to 5 years with acute rotavirus diarrhoea, based on a double-blind, randomised controlled trial from a developing country.
Saras Ramiya, 6 years ago

Patients with symptoms of peptic ulcer and who are at high risk of gastric cancer should be further examined for early detection of disease, says a leading gastrointestinal surgeon.

one year ago
While the type 1 cholecystokinin (CCK) receptor (CCK1R) malfunctions as a result of increased gallbladder cholesterol, ursodeoxycholic acid (UDCA) changes its conformation and prevents cholesterol gallstone formation.