Most Read Articles
3 months ago
New drug applications approved by US FDA as of 1 - 15 February 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Catherine J Calderwood, MA (Cantab), MRCOG; Omar I Thanoon, MRCOG, 3 years ago

One of the many early physiological adaptations of pregnancy involves changes in the coagulation system, which promote coagulation and impair fibrinolysis. The physiological goal is to prepare for the haemostatic challenge of delivery. A ‘side effect’ of this change is an increased risk of thrombosis. All pregnant women are therefore at risk of thrombosis, compared with non-pregnant women. This risk is manifest from early in the first trimester until 4−6 weeks post partum.

Roshini Claire Anthony, one year ago

Patients with pancreatic adenocarcinoma (PDAC) given adjuvant chemotherapy (ACT) appeared to have better overall survival (OS) than those given adjuvant chemoradiation therapy (ACRT), according to new research.

Statin therapy may reduce cirrhosis and its decompensation in CHB patients

Elaine Soliven
3 months ago

Statin therapy may reduce the risk of cirrhosis and its associated comorbidities in chronic hepatitis B (CHB) patients, according to a presentation at the 26th Conference of the Asian Pacific Association for the Study of the Liver (APASL) Annual Meeting 2017 held in Shanghai, China.

“Statins reduce cirrhosis and its decompensation in CHB patients independent of baseline comorbidity index and severity of liver disease,” said the researchers led by Dr Yi-Wen Huang from the Liver Center at Cathay General Hospital Medical Center in Taipei, Taiwan.

Statin therapy independently protected against cirrhosis (adjusted hazard ratio [adjHR], 0.133, 95 percent confidence interval [CI], 0.091–0.194; p<0.01) and decompensated cirrhosis (adjHR, 0.143, 95 percent CI, 0.100–0.206; p<0.01) in CHB patients after adjusting for potential confounders, medication use, and certain comorbidities such as hypertension, diabetes, hyperlipidaemia, obesity and nonalcoholic fatty liver disease. [APASL 2017, abstract PP 0052]

Hepatocellular carcinoma, hepatic coma, ascites, and use of aspirin and glucose- and lipid-lowering medications were notable risk factors associated with cirrhosis and decompensated cirrhosis.

Using data from the Taiwanese Health Insurance Research Database from 1997 to 2009, researchers conducted a population-based cohort study on 18,993 CHB patients. Statin users (≥28 cumulative defined daily doses [cDDD] per year) and nonstatin (<28 cDDD per year) users were identified and followed up until the progression of cirrhosis and its decompensation or until December 2009 or insurance withdrawal.

The findings were consistent with those of a previous study that established a dose-dependent reduction in the risk of cirrhosis and decompensated cirrhosis in CHB patients undergoing statin therapy. [Am J Gastroenterol  2016;doi:10.1038/ajg.2016.179]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacy - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
3 months ago
New drug applications approved by US FDA as of 1 - 15 February 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Catherine J Calderwood, MA (Cantab), MRCOG; Omar I Thanoon, MRCOG, 3 years ago

One of the many early physiological adaptations of pregnancy involves changes in the coagulation system, which promote coagulation and impair fibrinolysis. The physiological goal is to prepare for the haemostatic challenge of delivery. A ‘side effect’ of this change is an increased risk of thrombosis. All pregnant women are therefore at risk of thrombosis, compared with non-pregnant women. This risk is manifest from early in the first trimester until 4−6 weeks post partum.

Roshini Claire Anthony, one year ago

Patients with pancreatic adenocarcinoma (PDAC) given adjuvant chemotherapy (ACT) appeared to have better overall survival (OS) than those given adjuvant chemoradiation therapy (ACRT), according to new research.