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Yesterday
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Split-dose PEG for colonoscopy insufficient for bowel preparation in diabetic patients

26 Feb 2017

Preparation quality for colonoscopy is worse in individuals with diabetes than those without, a recent study has found. In addition, diabetic patients also experience longer cecal intubation and total procedure time.

A single-centre, prospective, investigator-blinded study was conducted to compare the efficacy and tolerability of split-dose polyethylene glycol (PEG) for diabetic vs nondiabetic patients. A total of 50 diabetic and 55 nondiabetic patients ingested 2 L PEG solution on the day before the procedure and another 2 L of the solution on the day of colonoscopy.

Researchers graded the quality of bowel preparation using the Ottawa scale.

A significant difference was seen in bowel preparation quality. Diabetic patients had a worse preparation except for mid colon compared with nondiabetic patients (total score 7.06 vs 5.54; p<0.001; right colon 2.28 vs 1.81; p<0.001; mid colon 1.70 vs 1.56; p=0.253; rectosigmoid colon 1.70 vs 1.14; p<0.001; fluid volume 1.38 vs 1.01; p=0.001).

Adequate preparation was achieved in about 70 percent of nondiabetic patients vs only 40 percent of diabetic patients (p=0.003), which also had longer cecal intubation time (6.4 vs 4.5; p=0.002) and total procedure time (22.1 vs 18.1; p=0.015).

There was no significant between-group difference in compliance and adverse events. In the diabetic group, a significant association was observed between inadequate bowel preparation and higher fasting plasma glucose (136 vs 121.8 mg/dL; p=0.016).

The results indicate that split-dose PEG preparation regimen is not adequate for optimal bowel preparation in diabetic patients undergoing colonoscopy, according to researchers.

Split-dose PEG is considered a standard bowel preparation regimen for colonoscopy in the general population, they added.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.