Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.

Sodium bicarbonate after heart surgery may harm kidneys in patients with IE

27 Jan 2017
Contamination of heater-cooler devices puts patients who undergo open-heart surgery at high risk

Administration of sodium bicarbonate appears to have no beneficial effects on patients with infective endocarditis (IE) undergoing heart surgery; instead, it may have potentially detrimental effects on renal function as demonstrated by increased postoperative peak serum creatinine (SCr) levels, according to a study.

The randomized, placebo-controlled clinical trial involved 70 patients aged between 20 and 80 years who were assigned to receive either sodium bicarbonate (n=35) or sodium chloride (n=35) as control. Sodium bicarbonate was given as a 0.5 mmol/kg loading dose for 1 hour with induction of anaethesia followed by a 0.15 mmol/kg/h infusion for 23 hours, whereas sodium chloride was similarly administered in equivalent volumes.

The primary outcome was the difference in SCr levels during the first 48 hours after surgery, with a difference in SCr >0.3 mg/dL considered clinically significant based on the Acute Kidney Injury Network criteria. The incidence of acute kidney injury, SCr level, estimated glomerular filtration rate and major morbidity endpoints were assessed postoperatively.

Secondary outcomes included the incidence of postoperative acute kidney injury (AKI), electrolyte abnormalities, major morbidity endpoints (permanent stroke, haemostatic re-exploration, AKI, prolonged ventilator care and deep sternal wound infection), ICU and hospital length of stay, and in-hospital mortality. Changes in eGFR were also assessed.

There were no differences observed between groups with regard to peak SCr during the first 48 hours postoperatively and the incidence of AKI. Compared with the control group, there was a greater postoperative increase in SCr above baseline in the bicarbonate group on postoperative day 2 (0.21 mg/dL vs 0.06 mg/dL; p=0.028) and postoperative day 5 (0.23 mg/dL vs 0.06 mg/dL, p=0.017). Postoperative renal and nonrenal function outcomes were similar between groups.
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Most Read Articles
Roshini Claire Anthony, 6 days ago

The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.

Yesterday
Overall survival (OS) and head and neck cancer (HNC)-specific survival vary among HNC sites, according to a study. In particular, cigarette smoking is a prognostic factor of OS and HNC-specific survival in patients with cancer of the oral cavity and oropharynx, whereas alcohol consumption is a prognostic factor of both survival outcomes in patients with cancer of the larynx.
18 Sep 2017
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
2 days ago
Adiponectin, but not leptin, is significantly correlated with proteinuria and its severity in systemic lupus erythematosus (SLE) nephritis, reveals a new cross-sectional study.