Most Read Articles
18 days ago
Regardless of dosing, nonvitamin K antagonist oral anticoagulants (NOACs) are more effective than warfarin for atrial fibrillation and safer in Asian than in non-Asian populations, a new meta-analysis shows.
6 days ago
Nonalcoholic fatty liver diseases (NAFLD) and serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) are independent predictors of incident type 2 diabetes, a new prospective study shows.
5 days ago
There appears to be no evidence supporting associations between physical activity and asthma control level, spirometric measurements and quality of life in children and adolescents with asthma, according to a study from Brazil.
5 days ago
There is a growing number of targeted therapies being approved for use in cancer therapy in the home setting, and this poses a potential risk among family member and caregivers, particularly those of reproductive risk age, a recent study suggests.

Sodium bicarbonate after heart surgery may harm kidneys in patients with IE

5 months ago
Contamination of heater-cooler devices puts patients who undergo open-heart surgery at high risk

Administration of sodium bicarbonate appears to have no beneficial effects on patients with infective endocarditis (IE) undergoing heart surgery; instead, it may have potentially detrimental effects on renal function as demonstrated by increased postoperative peak serum creatinine (SCr) levels, according to a study.

The randomized, placebo-controlled clinical trial involved 70 patients aged between 20 and 80 years who were assigned to receive either sodium bicarbonate (n=35) or sodium chloride (n=35) as control. Sodium bicarbonate was given as a 0.5 mmol/kg loading dose for 1 hour with induction of anaethesia followed by a 0.15 mmol/kg/h infusion for 23 hours, whereas sodium chloride was similarly administered in equivalent volumes.

The primary outcome was the difference in SCr levels during the first 48 hours after surgery, with a difference in SCr >0.3 mg/dL considered clinically significant based on the Acute Kidney Injury Network criteria. The incidence of acute kidney injury, SCr level, estimated glomerular filtration rate and major morbidity endpoints were assessed postoperatively.

Secondary outcomes included the incidence of postoperative acute kidney injury (AKI), electrolyte abnormalities, major morbidity endpoints (permanent stroke, haemostatic re-exploration, AKI, prolonged ventilator care and deep sternal wound infection), ICU and hospital length of stay, and in-hospital mortality. Changes in eGFR were also assessed.

There were no differences observed between groups with regard to peak SCr during the first 48 hours postoperatively and the incidence of AKI. Compared with the control group, there was a greater postoperative increase in SCr above baseline in the bicarbonate group on postoperative day 2 (0.21 mg/dL vs 0.06 mg/dL; p=0.028) and postoperative day 5 (0.23 mg/dL vs 0.06 mg/dL, p=0.017). Postoperative renal and nonrenal function outcomes were similar between groups.
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
18 days ago
Regardless of dosing, nonvitamin K antagonist oral anticoagulants (NOACs) are more effective than warfarin for atrial fibrillation and safer in Asian than in non-Asian populations, a new meta-analysis shows.
6 days ago
Nonalcoholic fatty liver diseases (NAFLD) and serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) are independent predictors of incident type 2 diabetes, a new prospective study shows.
5 days ago
There appears to be no evidence supporting associations between physical activity and asthma control level, spirometric measurements and quality of life in children and adolescents with asthma, according to a study from Brazil.
5 days ago
There is a growing number of targeted therapies being approved for use in cancer therapy in the home setting, and this poses a potential risk among family member and caregivers, particularly those of reproductive risk age, a recent study suggests.