Most Read Articles
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 months ago

Individuals with a history of migraine may be at a higher risk for ischaemic stroke within 1 month postsurgery, a recent study found.

Kathlin Ambrose, one year ago

Doctors uncertain on which cardiovascular (CV) risk calculator to use may consider opting for the Framingham General CV Disease risk score as studies have been performed in the country to validate it, says an expert.

one year ago
New drug applications approved by US FDA as of 16 - 31 Oct 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Sleep-trough morning BP surge associated with arterial stiffness

4 months ago

There is a direct correlation between sleep-trough (ST) morning blood pressure surge (MBPS) and aortic stiffness in untreated hypertension, which is mediated by an elevated average real variability (AVR) of 24-hour systolic BP, a recent study has found.

Furthermore, the adverse effects of MBPS could be due to its relation with arterial stiffness, mediated by short-term SBP variability.

To describe the association between MBPS, short-term BP variability and arterial stiffness, researchers measured carotid-femoral pulse wave velocity (cf-PWV, SphygmoCor) and 24-hour ambulatory BP in 602 consecutive patients with untreated hypertension (mean age 48 years; 61 percent men; office BP, 149/93 mm Hg).

Using self-reported sleep and wake times, researchers defined MBPS as ST, prewaking and rising. They calculated short-term BP variability as weighted 24-hour SBP SD and AVR of 24-hour SBP, which is the average of absolute differences between consecutive SBP readings.

Both ST-MBPS (r=0.16; p<0.001) and rising MBPS (r=0.12; p=0.003) demonstrated a direct association with cf-PWF, while prewaking MBPS did not show such relation (r=0.06; p=0.14).

After adjusting for age, sex, height, office mean arterial pressure, heart rate and renal function, only ST-MBPS showed an independent correlation with cf-PWF (t=1.96; p=0.04). However, this association was lost after further adjustment for weighted 24-hour SBP SD (p=0.13) or ARV (p=0.24).

Finally, ARV was a significant mediator of the association between ST-MBPS and cf-PWF (p=0.003), according to researchers.

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Most Read Articles
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Roshini Claire Anthony, 4 months ago

Individuals with a history of migraine may be at a higher risk for ischaemic stroke within 1 month postsurgery, a recent study found.

Kathlin Ambrose, one year ago

Doctors uncertain on which cardiovascular (CV) risk calculator to use may consider opting for the Framingham General CV Disease risk score as studies have been performed in the country to validate it, says an expert.

one year ago
New drug applications approved by US FDA as of 16 - 31 Oct 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.