Most Read Articles
2 years ago
Based on a population-based cohort study, pregnant women who underwent assisted reproductive technology, particularly following cryopreservation, are at greater risk for hypertensive disorders.
Kathlin Ambrose, one year ago
The outcome for patients experiencing out-of-hospital sudden cardiac arrest (OSCA) remains very poor in Malaysia. Local data shows that return of spontaneous circulation in OSCA patients stands at 17.4 percent, while survival to ward is a mere 4.3 percent. [Med J Malaysia 2008; 63:4–8]
Christina Lau, 3 years ago

The novel oral anticoagulant (OAC) dabigatran is better than warfarin for stroke prevention in Asian patients with atrial fibrillation (AF), according to a new analysis that included patients from Hong Kong.

one year ago
During the Diabetes Asia 2015 Conference, Professor Jean Claude Mbanya discussed the role of sulphonylureas in today’s management of type 2 diabetes (T2D). Important points from his presentation are summarized below.

Sleep-trough morning BP surge associated with arterial stiffness

6 months ago

There is a direct correlation between sleep-trough (ST) morning blood pressure surge (MBPS) and aortic stiffness in untreated hypertension, which is mediated by an elevated average real variability (AVR) of 24-hour systolic BP, a recent study has found.

Furthermore, the adverse effects of MBPS could be due to its relation with arterial stiffness, mediated by short-term SBP variability.

To describe the association between MBPS, short-term BP variability and arterial stiffness, researchers measured carotid-femoral pulse wave velocity (cf-PWV, SphygmoCor) and 24-hour ambulatory BP in 602 consecutive patients with untreated hypertension (mean age 48 years; 61 percent men; office BP, 149/93 mm Hg).

Using self-reported sleep and wake times, researchers defined MBPS as ST, prewaking and rising. They calculated short-term BP variability as weighted 24-hour SBP SD and AVR of 24-hour SBP, which is the average of absolute differences between consecutive SBP readings.

Both ST-MBPS (r=0.16; p<0.001) and rising MBPS (r=0.12; p=0.003) demonstrated a direct association with cf-PWF, while prewaking MBPS did not show such relation (r=0.06; p=0.14).

After adjusting for age, sex, height, office mean arterial pressure, heart rate and renal function, only ST-MBPS showed an independent correlation with cf-PWF (t=1.96; p=0.04). However, this association was lost after further adjustment for weighted 24-hour SBP SD (p=0.13) or ARV (p=0.24).

Finally, ARV was a significant mediator of the association between ST-MBPS and cf-PWF (p=0.003), according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
2 years ago
Based on a population-based cohort study, pregnant women who underwent assisted reproductive technology, particularly following cryopreservation, are at greater risk for hypertensive disorders.
Kathlin Ambrose, one year ago
The outcome for patients experiencing out-of-hospital sudden cardiac arrest (OSCA) remains very poor in Malaysia. Local data shows that return of spontaneous circulation in OSCA patients stands at 17.4 percent, while survival to ward is a mere 4.3 percent. [Med J Malaysia 2008; 63:4–8]
Christina Lau, 3 years ago

The novel oral anticoagulant (OAC) dabigatran is better than warfarin for stroke prevention in Asian patients with atrial fibrillation (AF), according to a new analysis that included patients from Hong Kong.

one year ago
During the Diabetes Asia 2015 Conference, Professor Jean Claude Mbanya discussed the role of sulphonylureas in today’s management of type 2 diabetes (T2D). Important points from his presentation are summarized below.