Most Read Articles
01 Mar 2016
The present understanding on the pathogenesis, diagnosis, and management of rheumatic heart disease were discussed in a review.
05 Jun 2015
Acute rheumatic fever and rheumatic heart disease continue to cause serious problems and hospitalisations according to a study in Zimbabwe.
03 Jun 2017
Both high and low values of the atherogenic index of plasma are independently associated with all-cause mortality, a new study reveals.
18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.

Sleep-trough morning BP surge associated with arterial stiffness

10 Jan 2017

There is a direct correlation between sleep-trough (ST) morning blood pressure surge (MBPS) and aortic stiffness in untreated hypertension, which is mediated by an elevated average real variability (AVR) of 24-hour systolic BP, a recent study has found.

Furthermore, the adverse effects of MBPS could be due to its relation with arterial stiffness, mediated by short-term SBP variability.

To describe the association between MBPS, short-term BP variability and arterial stiffness, researchers measured carotid-femoral pulse wave velocity (cf-PWV, SphygmoCor) and 24-hour ambulatory BP in 602 consecutive patients with untreated hypertension (mean age 48 years; 61 percent men; office BP, 149/93 mm Hg).

Using self-reported sleep and wake times, researchers defined MBPS as ST, prewaking and rising. They calculated short-term BP variability as weighted 24-hour SBP SD and AVR of 24-hour SBP, which is the average of absolute differences between consecutive SBP readings.

Both ST-MBPS (r=0.16; p<0.001) and rising MBPS (r=0.12; p=0.003) demonstrated a direct association with cf-PWF, while prewaking MBPS did not show such relation (r=0.06; p=0.14).

After adjusting for age, sex, height, office mean arterial pressure, heart rate and renal function, only ST-MBPS showed an independent correlation with cf-PWF (t=1.96; p=0.04). However, this association was lost after further adjustment for weighted 24-hour SBP SD (p=0.13) or ARV (p=0.24).

Finally, ARV was a significant mediator of the association between ST-MBPS and cf-PWF (p=0.003), according to researchers.

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Most Read Articles
01 Mar 2016
The present understanding on the pathogenesis, diagnosis, and management of rheumatic heart disease were discussed in a review.
05 Jun 2015
Acute rheumatic fever and rheumatic heart disease continue to cause serious problems and hospitalisations according to a study in Zimbabwe.
03 Jun 2017
Both high and low values of the atherogenic index of plasma are independently associated with all-cause mortality, a new study reveals.
18 Aug 2016
Chronic kidney disease (CKD), regardless of the stage, appears to have no direct effect on cardiovascular mortality within 180 days and 2 years from digoxin treatment initiation in treatment-naïve patients with non-valvular atrial fibrillation (AF), a Danish cohort study suggests.