Most Read Articles
27 Sep 2017
Sleep problems appear to be associated with progression of lower urinary tract symptoms (LUTS) in men with the urologic condition and with LUTS development among asymptomatic men, according to data from the REDUCE* study.
Tristan Manalac, 10 Oct 2017
Despite being common, less than half of Singaporean women have sought medical attention for urinary incontinence for fear of surgery, embarrassment and other misconceptions, a new study from Singapore has found
30 Jul 2016
Long-term testosterone replacement therapy (TRT) is beneficial in men with late-onset hypogonadism (LOH) in a study and is even associated with improvement in sexual function and vitality, physical pain, general health, and overall health-related quality of life (HRQoL).
6 days ago
Physiotherapy and behaviour therapy appear to be effective interventions in females with overactive bladder syndrome, with those who have had no previous exposure to the treatments benefitting from post-therapy effects, a recent study has shown.

Sleep problems tied to LUTS development, progression

27 Sep 2017

Sleep problems appear to be associated with progression of lower urinary tract symptoms (LUTS) in men with the urologic condition and with LUTS development among asymptomatic men, according to data from the REDUCE* study.

Researchers examined the association between sleep, measured by the 6-item Medical Outcomes Study Sleep Scale (MOS-Sleep) survey, and LUTS development and progression in a cohort of 1,452 asymptomatic males and 1,136 male LUTS patients. All participants were followed for 4 years, during which the International Prostate Symptom Score (IPSS) was obtained at baseline and every 6 months.

During follow-up, 14 percent of men in the asymptomatic group developed LUTS and 50 percent in the LUTS group demonstrated progression. Multivariable Cox analysis found that higher sleep scores were associated with increased risk of LUTS development among asymptomatic men (quartile 4 vs 1: hazard ratio [HR] 1.50; 95 percent CI, 1.00 to 2.23; p=0.048) and heightened risk of LUTS progression among symptomatic men (HR per 10-points increase in sleep score, 1.06; 1.02 to 1.12; p=0.029).

The present data, if confirmed, suggest that sleep problems may precede LUTS, researchers said. In light of this, more studies are needed to examine whether treating sleep problems may improve LUTS.

Long-term insomnia and nocturia are frequently associated in the elderly. Evidence shows that poor sleep quality may increase arousal during sleep, leading to secondary nocturia. Furthermore, prostatic hyperplasia has been shown to cause nocturia, which in turn induces a sleep disorder. [Nat Sci Sleep 2013;5:7–13]

The mechanism underlying the development of sleep disorders is said to involve imbalances in steroid hormone action, sympathetic nervous system activity and immune dysfunction, all of which are considered to potentially contribute to the development of symptomatic benign prostatic hyperplasia and bladder outlet obstruction. [Curr Urol Rep 2012;13:407-12]

*Reduction by Dutasteride of Prostate Cancer Events

Editor's Recommendations
Most Read Articles
27 Sep 2017
Sleep problems appear to be associated with progression of lower urinary tract symptoms (LUTS) in men with the urologic condition and with LUTS development among asymptomatic men, according to data from the REDUCE* study.
Tristan Manalac, 10 Oct 2017
Despite being common, less than half of Singaporean women have sought medical attention for urinary incontinence for fear of surgery, embarrassment and other misconceptions, a new study from Singapore has found
30 Jul 2016
Long-term testosterone replacement therapy (TRT) is beneficial in men with late-onset hypogonadism (LOH) in a study and is even associated with improvement in sexual function and vitality, physical pain, general health, and overall health-related quality of life (HRQoL).
6 days ago
Physiotherapy and behaviour therapy appear to be effective interventions in females with overactive bladder syndrome, with those who have had no previous exposure to the treatments benefitting from post-therapy effects, a recent study has shown.