Most Read Articles
09 Oct 2017
Pleural fluid lactic dehydrogenase (LDH) and glucose are useful parameters for evaluating severity of paediatric community acquired complicated pneumonia (PCACP), according to a study. Measurements of both parameters strongly correlate with prolonged hospitalization as an indirect indicator of disease severity.
5 days ago
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
6 days ago
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
Elaine Tan, 14 Aug 2017

Complicated and uncomplicated urinary tract infections (UTIs) in adults and children should be managed by identifying and treating predisposing or underlying risk factors, with antimicrobial treatment, if needed, based on urine culture results and regional antibiotic resistance patterns, according to new guidelines of the Urological Association of Asia (UAA) and Asian Association of UTI and STD (AAUS).

Severe coma, renal failure predict mortality in elderly with dengue

07 Oct 2017
Dengue cases in Sri Lanka, India have been recorded twice as many compared to last year.

Survival rate in geriatric patients with dengue fever is high, given the absence of any of the following predictors: severe coma, severe hepatitis, renal failure and being bedridden, a new retrospective case-control study has shown.

In contrast, those with at least two predictors have an almost 60 percent mortality rate.

Medical records of 627 elderly patients (mean age 74.09±6.28 years) who were admitted into a tertiary medical hospital during the 2015 dengue fever outbreak in Taiwan were accessed. Of these, 27 patients had died, resulting in a mortality rate of 4.3 percent.

In terms of comorbidity, patients who died had significantly higher percentages of pressure ulcer (p=0.015), anaemia (p=0.04), respiratory failure (p<0.001), diabetes mellitus (p=0.038) and coronary artery disease (p=0.04), among other conditions, than those without mortality.

In multivariate logistic regression analysis, severe coma (adjusted odds ratio [OR], 11.36; 95 percent CI, 1.89 to 68.19; p=0.08), being bedridden (adjusted OR, 10.46; 1.58 to 69.16; p=0.015), severe hepatitis (adjusted OR, 96.08; 14.11 to 654.39; p<0.001) and renal failure (adjusted OR, 6.03; 1.50 to 24.246; p=0.011) were the four significant predictors of mortality.

When combined, all four predictors yielded a sensitivity of 70.37 percent for patients with at least one predictor. The specificity, positive predictive value (PPV) and negative predictive value (NPV) were 88.17, 21.11 and 98.51 percent, respectively.

In comparison, sensitivity for those with at least two predictors was 33.33 percent. The corresponding specificity, PPV and NPV were 99.44, 57.14 and 98.51 percent.

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Most Read Articles
09 Oct 2017
Pleural fluid lactic dehydrogenase (LDH) and glucose are useful parameters for evaluating severity of paediatric community acquired complicated pneumonia (PCACP), according to a study. Measurements of both parameters strongly correlate with prolonged hospitalization as an indirect indicator of disease severity.
5 days ago
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
6 days ago
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
Elaine Tan, 14 Aug 2017

Complicated and uncomplicated urinary tract infections (UTIs) in adults and children should be managed by identifying and treating predisposing or underlying risk factors, with antimicrobial treatment, if needed, based on urine culture results and regional antibiotic resistance patterns, according to new guidelines of the Urological Association of Asia (UAA) and Asian Association of UTI and STD (AAUS).