Most Read Articles
Jairia Dela Cruz, 23 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 5 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
7 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.

Serum pepsinogen potential biomarker for Kazakh early gastric cancer

3 months ago

The serum pepsinogen test—which is relatively simple, inexpensive, sensitive and specific—is a potentially viable method for the screening and detection of Kazakh early gastric cancer, a new study claims.

The study included 464 participants who received endoscopic examination from gastrointestinal clinics. Those with prior histories of gastric surgery, chemotherapy, infections by Heliobacter pylori, severe systemic diseases and anti-coagulant therapy were excluded from the study.

Of the participants, 106 had gastric cancer 160 served as normal controls. Patients with gastric cancer were divided into two, according to the progression of the cancer: early gastric cancer and advanced gastric cancer. Enzyme-linked immunosorbent assay and flow fluorescence assays were used to measure the serum pepsinogen levels.

According to the Lauren classification, 52 participants (49.1 percent) had intestinal cancers and 50 (47.2 percent) had diffuse type cancers.

In the gastric cancer and atrophic gastritis groups, the levels of pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly higher than those in the superficial gastritis group (p<0.05). There was no significant difference observed between the early and advanced gastric cancer groups.

Further analysis revealed that the sensitivity of serum pepsinogen in diagnosing gastric cancer was 80.5 percent while the specificity was 89.8 percent. These were obtained using ≤64 ng/mL and ≤4.5 as the cut-off points for pepsinogen I concentration and pepsinogen I/pepsinogen II ratio, respectively.

Finally, the area under the curve for using the pepsinogen I/pepsinogen II ratio to diagnose gastric cancer was found to be 0.949. This ratio was also found to be significantly lower in Kazakh early gastric cancer compared to superficial and atrophic gastritis.

The findings thus show that serum pepsinogen may be a viable circulating biomarker for diagnosing Kazakh early gastric cancer.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Jairia Dela Cruz, 23 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 5 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
7 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.