Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
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Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Serum chemerin tied to quality of life in colorectal cancer survivors

17 May 2017

Serum chemerin levels have a weak but significant association with quality of life (QoL) of survivors of colorectal cancer (CRC), a new study shows.

The study included 110 survivors (mean age 56.29±9.27 years; 50 percent male) of stage 2 or 3 CRC. All participants had completed standard treatment regimens within 6 weeks and 1 year before study enrolment; all were above the age of 20 years. Those with histories of cancer, chronic diseases and abnormal liver and kidney function were excluded.

Participant QoL was assessed using the Functional Assessment of Cancer Therapy (FACT)-General (FACT-G), total FACT-cancer-related (FACT-C) and total FACT-fatigue (FACT-F) questionnaires. Serum chemerin, white blood cell count, total cholesterol, triglyceride and fasting insulin levels, among other markers, were measured from blood samples.

The mean serum chemerin level of the participants was 104.69±14.31 ng/mL.Stage 2 and 3 CRC was reported in 49.1 (n=54) and 50.9 (n=56) percent of the participants, respectively. Furthermore, 91.8 (n=101) and 8.2 (n=9) percent were treated with surgery pluschemotherapy and surgery plus chemoradiotherapy, respectively.

Mean FACT-G, FACT-C and FACT-F scores were 80.57±13.68, 100.89±16.53 and 122.40±19.40, respectively. FACT-G scores were significantly negatively correlated with age (p=0.04), fat percentage (p=0.04), triglyceride levels (p=0.02), high-sensitivity C-reactive protein (hsCRP; p=0.02) and serum chemerin levels (p<0.01).

Similarly, FACT-C scores were negatively associated with triglyceride (p=0.02), hsCRP (p=0.02), fat percentage (p=0.04), age (p=0.04) and serum chemerin levels (p<0.01). On the other hand, only triglyceride (p=0.02) and serum chemerin (p<0.01) were significantly negatively associated with FACT-F scores.

Finally, even after adjusting for potential confounders, FACT-G (β, -0.12; p=0.02), FACT-C (β, -0.14; p=0.02) and FACT-F (β, -0.20; p<0.01) were still significantly independently associated with serum chemerin.

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Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.