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one year ago
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Saras Ramiya, 6 years ago

Patients with symptoms of peptic ulcer and who are at high risk of gastric cancer should be further examined for early detection of disease, says a leading gastrointestinal surgeon.

one year ago
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Serum chemerin tied to quality of life in colorectal cancer survivors

2 months ago

Serum chemerin levels have a weak but significant association with quality of life (QoL) of survivors of colorectal cancer (CRC), a new study shows.

The study included 110 survivors (mean age 56.29±9.27 years; 50 percent male) of stage 2 or 3 CRC. All participants had completed standard treatment regimens within 6 weeks and 1 year before study enrolment; all were above the age of 20 years. Those with histories of cancer, chronic diseases and abnormal liver and kidney function were excluded.

Participant QoL was assessed using the Functional Assessment of Cancer Therapy (FACT)-General (FACT-G), total FACT-cancer-related (FACT-C) and total FACT-fatigue (FACT-F) questionnaires. Serum chemerin, white blood cell count, total cholesterol, triglyceride and fasting insulin levels, among other markers, were measured from blood samples.

The mean serum chemerin level of the participants was 104.69±14.31 ng/mL.Stage 2 and 3 CRC was reported in 49.1 (n=54) and 50.9 (n=56) percent of the participants, respectively. Furthermore, 91.8 (n=101) and 8.2 (n=9) percent were treated with surgery pluschemotherapy and surgery plus chemoradiotherapy, respectively.

Mean FACT-G, FACT-C and FACT-F scores were 80.57±13.68, 100.89±16.53 and 122.40±19.40, respectively. FACT-G scores were significantly negatively correlated with age (p=0.04), fat percentage (p=0.04), triglyceride levels (p=0.02), high-sensitivity C-reactive protein (hsCRP; p=0.02) and serum chemerin levels (p<0.01).

Similarly, FACT-C scores were negatively associated with triglyceride (p=0.02), hsCRP (p=0.02), fat percentage (p=0.04), age (p=0.04) and serum chemerin levels (p<0.01). On the other hand, only triglyceride (p=0.02) and serum chemerin (p<0.01) were significantly negatively associated with FACT-F scores.

Finally, even after adjusting for potential confounders, FACT-G (β, -0.12; p=0.02), FACT-C (β, -0.14; p=0.02) and FACT-F (β, -0.20; p<0.01) were still significantly independently associated with serum chemerin.

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one year ago
Entecavir yields more favourable survival outcomes than lamivudine treatment in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), as shown in a retrospective cohort study.
one year ago
Saccharomyces boulardii has favourable safety and efficacy in the treatment of children aged 3 months to 5 years with acute rotavirus diarrhoea, based on a double-blind, randomised controlled trial from a developing country.
Saras Ramiya, 6 years ago

Patients with symptoms of peptic ulcer and who are at high risk of gastric cancer should be further examined for early detection of disease, says a leading gastrointestinal surgeon.

one year ago
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