Most Read Articles
01 Mar 2016
Cannabinoid hyperemesis syndrome (CHS) should be regarded as an important differential diagnosis in recurrent nausea and vomiting, according to a retrospective cohort study .
Kavitha G. Shekar, 08 Feb 2016

One in 7 patients diagnosed with colorectal cancer (CRC) are below the recommended average-risk screening age of 50, according to a population-based cohort study, which suggests the need for CRC screening policy changes.

11 Apr 2016
Surveillance practice in colorectal adenomas could still be improved, as noted in a Dutch community-based study.
Roshini Claire Anthony, 22 Apr 2016
A once-daily oral dose of the direct-acting antiviral agents (DAAs) ledipasvir/sofosbuvir (LDV/SOF) is safe and effective in treating adolescent genotype 1 (GT1) hepatitis C (HCV) patients, according to results of a study presented at the annual meeting of the European Association for the Study of the Liver (EASL) International Liver Congress™ (ILC) 2016 in Barcelona, Spain.

Serum chemerin tied to quality of life in colorectal cancer survivors

17 May 2017

Serum chemerin levels have a weak but significant association with quality of life (QoL) of survivors of colorectal cancer (CRC), a new study shows.

The study included 110 survivors (mean age 56.29±9.27 years; 50 percent male) of stage 2 or 3 CRC. All participants had completed standard treatment regimens within 6 weeks and 1 year before study enrolment; all were above the age of 20 years. Those with histories of cancer, chronic diseases and abnormal liver and kidney function were excluded.

Participant QoL was assessed using the Functional Assessment of Cancer Therapy (FACT)-General (FACT-G), total FACT-cancer-related (FACT-C) and total FACT-fatigue (FACT-F) questionnaires. Serum chemerin, white blood cell count, total cholesterol, triglyceride and fasting insulin levels, among other markers, were measured from blood samples.

The mean serum chemerin level of the participants was 104.69±14.31 ng/mL.Stage 2 and 3 CRC was reported in 49.1 (n=54) and 50.9 (n=56) percent of the participants, respectively. Furthermore, 91.8 (n=101) and 8.2 (n=9) percent were treated with surgery pluschemotherapy and surgery plus chemoradiotherapy, respectively.

Mean FACT-G, FACT-C and FACT-F scores were 80.57±13.68, 100.89±16.53 and 122.40±19.40, respectively. FACT-G scores were significantly negatively correlated with age (p=0.04), fat percentage (p=0.04), triglyceride levels (p=0.02), high-sensitivity C-reactive protein (hsCRP; p=0.02) and serum chemerin levels (p<0.01).

Similarly, FACT-C scores were negatively associated with triglyceride (p=0.02), hsCRP (p=0.02), fat percentage (p=0.04), age (p=0.04) and serum chemerin levels (p<0.01). On the other hand, only triglyceride (p=0.02) and serum chemerin (p<0.01) were significantly negatively associated with FACT-F scores.

Finally, even after adjusting for potential confounders, FACT-G (β, -0.12; p=0.02), FACT-C (β, -0.14; p=0.02) and FACT-F (β, -0.20; p<0.01) were still significantly independently associated with serum chemerin.

Editor's Recommendations
Most Read Articles
01 Mar 2016
Cannabinoid hyperemesis syndrome (CHS) should be regarded as an important differential diagnosis in recurrent nausea and vomiting, according to a retrospective cohort study .
Kavitha G. Shekar, 08 Feb 2016

One in 7 patients diagnosed with colorectal cancer (CRC) are below the recommended average-risk screening age of 50, according to a population-based cohort study, which suggests the need for CRC screening policy changes.

11 Apr 2016
Surveillance practice in colorectal adenomas could still be improved, as noted in a Dutch community-based study.
Roshini Claire Anthony, 22 Apr 2016
A once-daily oral dose of the direct-acting antiviral agents (DAAs) ledipasvir/sofosbuvir (LDV/SOF) is safe and effective in treating adolescent genotype 1 (GT1) hepatitis C (HCV) patients, according to results of a study presented at the annual meeting of the European Association for the Study of the Liver (EASL) International Liver Congress™ (ILC) 2016 in Barcelona, Spain.