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Serum AST, ALT, GGT, ALP predict incident type 2 diabetes

16 Jul 2017
The current blood glucose monitor requires a disposable test strip and a small drop of blood.

Nonalcoholic fatty liver diseases (NAFLD) and serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) are independent predictors of incident type 2 diabetes, a new prospective study shows.

Multiple cox regression models showed that NAFLD (hazard ratio [HR], 2.08; 95 percent CI, 1.93 to 2.23; p<0.001) and elevated levels of ALT (HR, 1.27; 1.16 to 1.38; p<0.001), AST (HR, 1.23; 1.13 to 1.34; p<0.001), GGT (HR, 1.58; 1.46 to 1.72; p<0.001) and ALP (HR, 1.37; 1.17 to 1.60; p<0.001) were independent risk factors for diabetes in males after adjusting for confounders.

Similarly, NAFLD (HR, 2.65; 2.43 to 2.88; p<0.001) and elevated levels of ALT (HR, 1.56; 1.37 to 1.77; p<0.001), AST (HR, 1.18; 1.04 to 1.34; p<0.01), GGT (HR, 1.48; 1.32 to 1.65; p<0.001) and ALP (HR, 1.44; 1.25 to 1.66; p<0.001) were independent predictors of diabetes in females.

Defined as being in the top 25 percent of abnormal values, extremely high levels of ALT (HR, 1.44; 1.24 to 1.67; p<0.001), AST (HR, 1.36; 1.17 to 1.58; p<0.001), GGT (HR 1.58; 1.37 to 1.84; p<0.001) and ALP (HR, 1.54; 1.16 to 2.03; p<0.01) were associated with higher risks of incident diabetes in males.

On the other hand, only extremely high AST levels (HR, 1.58; 1.27 to 1.96; p<0.001) resulted in higher risks of incident diabetes in females.

The study involved 132,377 healthy, nondiabetic individuals between the ages of 35 and 79. Of these, 6,555 (3,734 males; 2,821 females) developed incident diabetes over the course of the study. The incidence rates in males in females were 9.97 and 7.11 per 1,000 person-years, respectively.

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Most Read Articles
4 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 5 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
Yesterday
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4 days ago
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