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SCCA2 a potential marker of disease activity, treatment efficacy in atopic dermatitis

31 Aug 2017

Serum levels of squamous cell carcinoma antigen 2 (SCCA2) are indicative of disease severity and clinical type of atopic dermatitis (AD), according to a recent study, suggesting that SCCA2 may be a novel and useful marker for evaluating disease activity and treatment efficacy in AD.

The study included 240 adult patients with AD and 25 healthy controls. Serum SCCA2 levels were measured using an enzyme-linked immunosorbent assay. SCCA2 was analysed in relation to clinical characteristics and laboratory parameters including thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), blood eosinophils, total IgE, and specific IgE (eg, Japanese cedar pollen, Dermatophagoides farina, Candida, malassezia, Staphylococcal enterotoxin B).

Other assessments included the expression of SCCA2 in AD eruption and the effect of treatment on serum SCCA2.

Serum SCCA2 levels were positively associated with disease severity, levels of TARC, LDH, eosinophil counts and IgE levels. Robust SCCA2 expression was identified in the supra basal keratinocytes in the epidermis of AD patients.

When SCCA2 was analysed by clinical types of AD, serum levels were significantly higher in patients with erythroderma type vs other types. In patients whose lesions were not widely distributed, such as those with limb type, SCCA2 levels were lower. No association was noted between the severity of prurigo type AD and serum levels of SCCA2.

Aside from reflecting the extent of lesional skin, SCCA2 levels were also likely to better indicate the extent of chronic inflammation.

Overall, SCCA2 levels decreased after treatment for AD.

Known as a tumour biomarker for various squamous cell tumours, SCCA comprises two nearly identical proteins, SCCA1 and SCCA2. Both proteins belong to the ovalbumin-serpin proteinase inhibitor family and have shown activity against different proteases. [Clinic Rev Allergy Immunol 2013;45:267–280]

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.