Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.

Scarce information comparing treatments for HA and RES RRMS

18 Mar 2017
Multiple Sclerosis (MS) is a debilitating disease, in which nerve damage affects communications between the brain and body. HSCT could provide the therapeutic answer for MS patients.

There is a shortage of information comparing the efficacy of treatments for patients with highly active (HA) and rapidly evolving severe (RES) relapsing-remitting multiple sclerosis (RRMS), resulting in low-confidence conclusions, a new systematic literature review reveals.

The present review accessed the databases of The Cochrane Library, Embase and Medline, the US Food and Drug Administration, ClinicalTrials.gov and the European Medicines Agency. Studies that investigated treatments for HA or RES RRMS recommended for reimbursements in the UK were included.

A Bayesian network meta-analysis (NMA) was performed on the collected data to determine the efficacy of fingolimod vs dimethyl fumarate (DMF) for HA RRMS vs natalizumab for RES RRMS.

After applying the inclusion and exclusion criteria, the review yielded 8 studies eligible for inclusion: four on RES RRMS and five on HA RRMS (one study reported on both). Of these, only two for HA RRMS and three for RES RRMS had adequate patient subgroup data for NMA.

The network for HA RRMS associated fingolimod with DMF via placebo as the common comparator. Both fingolimod and DMF produced significant improvements over 3 months. However, there was no significant difference between fingolimod and DMF.

In the network for RES RRMS, fingolimod was associated with natalizumab through placebo. Similarly, both treatments yielded significant improvements over placebo but not over each other.

More importantly, the systematic literature review and subsequent NMA revealed the lack of existing data and information comparing treatments between multiple sclerosis patient subgroups. This may impose important limitations in creating recommendations for clinical guidelines.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.