Most Read Articles
18 days ago
Regardless of dosing, nonvitamin K antagonist oral anticoagulants (NOACs) are more effective than warfarin for atrial fibrillation and safer in Asian than in non-Asian populations, a new meta-analysis shows.
6 days ago
Nonalcoholic fatty liver diseases (NAFLD) and serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) are independent predictors of incident type 2 diabetes, a new prospective study shows.
5 days ago
There appears to be no evidence supporting associations between physical activity and asthma control level, spirometric measurements and quality of life in children and adolescents with asthma, according to a study from Brazil.
5 days ago
There is a growing number of targeted therapies being approved for use in cancer therapy in the home setting, and this poses a potential risk among family member and caregivers, particularly those of reproductive risk age, a recent study suggests.

Scarce information comparing treatments for HA and RES RRMS

4 months ago
Multiple Sclerosis (MS) is a debilitating disease, in which nerve damage affects communications between the brain and body. HSCT could provide the therapeutic answer for MS patients.

There is a shortage of information comparing the efficacy of treatments for patients with highly active (HA) and rapidly evolving severe (RES) relapsing-remitting multiple sclerosis (RRMS), resulting in low-confidence conclusions, a new systematic literature review reveals.

The present review accessed the databases of The Cochrane Library, Embase and Medline, the US Food and Drug Administration, ClinicalTrials.gov and the European Medicines Agency. Studies that investigated treatments for HA or RES RRMS recommended for reimbursements in the UK were included.

A Bayesian network meta-analysis (NMA) was performed on the collected data to determine the efficacy of fingolimod vs dimethyl fumarate (DMF) for HA RRMS vs natalizumab for RES RRMS.

After applying the inclusion and exclusion criteria, the review yielded 8 studies eligible for inclusion: four on RES RRMS and five on HA RRMS (one study reported on both). Of these, only two for HA RRMS and three for RES RRMS had adequate patient subgroup data for NMA.

The network for HA RRMS associated fingolimod with DMF via placebo as the common comparator. Both fingolimod and DMF produced significant improvements over 3 months. However, there was no significant difference between fingolimod and DMF.

In the network for RES RRMS, fingolimod was associated with natalizumab through placebo. Similarly, both treatments yielded significant improvements over placebo but not over each other.

More importantly, the systematic literature review and subsequent NMA revealed the lack of existing data and information comparing treatments between multiple sclerosis patient subgroups. This may impose important limitations in creating recommendations for clinical guidelines.

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Most Read Articles
18 days ago
Regardless of dosing, nonvitamin K antagonist oral anticoagulants (NOACs) are more effective than warfarin for atrial fibrillation and safer in Asian than in non-Asian populations, a new meta-analysis shows.
6 days ago
Nonalcoholic fatty liver diseases (NAFLD) and serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) are independent predictors of incident type 2 diabetes, a new prospective study shows.
5 days ago
There appears to be no evidence supporting associations between physical activity and asthma control level, spirometric measurements and quality of life in children and adolescents with asthma, according to a study from Brazil.
5 days ago
There is a growing number of targeted therapies being approved for use in cancer therapy in the home setting, and this poses a potential risk among family member and caregivers, particularly those of reproductive risk age, a recent study suggests.