Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

Sarcopenia, weight loss tied to elevated mortality risk

28 Jul 2017

It appears that sarcopenic obesity confers a comparable risk of mortality as sarcopenia alone, and that weight loss plus sarcopenia presents the greatest risk, suggests a recent study.

Community-dwelling older adults (mean age 66.2 years; 54.4 percent women) from the English Longitudinal Study of Ageing were recruited to examine the association of sarcopenic obesity and changes in muscle strength and weight with the risk of mortality.

Researchers measured handgrip strength and body mass index (BMI; in kg/m2) at baseline and at a 4-year follow-up. Individual participant data were linked with death records from National Health Service registries. Sarcopenic obesity referred to obese individuals (BMI, ≥30) in the lowest tertile of sex-specific grip strength (<35.3 kg for men and <19.6 kg for women).

During a mean follow-up of 8 years, a total of 906 deaths occurred. Compared with the reference group (normal BMI and highest handgrip tertile), reduction of grip strength within each BMI category increased the risk of all-cause mortality.

A little difference was observed in the risk between normal BMI (hazard ratio [HR], 3.25; 95 percent CI, 1.86 to 5.65), overweight (HR, 2.50; 1.44 to 4.35) and obesity (HR, 2.66; 1.86 to 3.80) for participants in the lowest handgrip tertile after adjusting for covariates.

Participants who had weight loss over 4 years (HR, 2.21; 1.32 to 3.71) and/or reduced hand grip strength (HR, 1.53; 10.07 to 2.17) had significantly higher risk of all-cause mortality than those with stable weight and grip strength. Moreover, those with both weight loss and reduced strength (HR, 3.77; 2.54 to 5.60) had the highest risk.

“Age-related sarcopenia describes the loss of muscle strength and often accompanies an increase in adiposity in the elderly,” researchers noted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.