Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Salivary CSF-1 levels tied to periodontitis, age, manifest caries

11 Aug 2017
Roughly one in three adults suffer from the gum disease worldwide

Age, periodontitis, muscle and joint diseases, malignancies, smoking, and manifest caries are all factors that are associated significantly with salivary concentrations of colony stimulating factor (CSF)-1, a new study has shown.

Analysis of mean salivary CSF-1 levels in 441 individuals (mean age 48.5±16.8 years; 50.6 percent female) showed that females (873.7±677.6 pg/mL) and males (927.3±661.5 pg/mL) had comparable levels even after adjusting for total amount of protein.

In contrast, the level of salivary CSF-1 was significantly lower in smokers compared with nonsmokers (759.6±595.5 vs 928.8±682.2 pg/mL; p<0.05). The statistically significant difference disappeared after controlling for total amount of protein.

Participants were divided into three age groups: <40 years (n=150), 40 to 64 years (n=199) and >64 years (n=90). Those who were above 64 years had significantly higher CSF-1 levels than the other two age groups, even after adjusting for total protein amount. Age was also significantly positively associated with CSF-1 levels (p<0.001).

CSF-1 levels were significantly higher in participants with periodontitis than in those without (973.3±725.2 vs 802.1±532.9 pg/mL), even after adjusting for manifest caries. The significant association was lost after adjusting for total salivary protein.

Those with manifest caries lesions (MCL) ≥3 (1,158.2±964.5 pg/mL) had significantly greater salivary CSF-1 than those with one to two MCLs (945.0±641.5 pg/mL) and without MCL (852.2±626.2 pg/mL). Controlling for total salivary protein removed the significant association. MCL was significantly positively correlated with CSF-1 levels (p=0.001).

Finally, participants with tumours and muscle and joint pains had higher CSF-1 levels compared with those without the conditions. The differences did not reach statistical significance.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.