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Risk of VTE higher in patients with primary Sjögren syndrome

31 Aug 2017

Population-based evidence shows a substantially increased risk of venous thromboembolism (VTE) among patients with primary Sjögren syndrome (pSS), especially within the first year after SS diagnosis.

Researchers created a study cohort of all patients with incident SS using a population database that includes all residents of British Columbia, Canada, and up to 10 controls from the general population matched for age, sex and entry time to estimate the future risk and time trends of VTE in individuals with newly diagnosed PSS.

Incidence rates (IRs) of pulmonary embolism (PE), deep vein thrombosis (DVT) and VTE were compared between the two groups according to SS disease duration. Hazard ratio (HR) was also calculated, adjusting for confounders.

Of the 1,175 incident pSS cases (mean age 56.7 years; 87.6 percent women), the respective IRs of PE, DVT and VTE were 3.9, 2.8 and 5.2 per 1,000 person-years. The corresponding rates among controls were 0.9, 0.8 and 1.4 per 1,000 person-years.

In comparison with non-SS individuals, the multivariable HR among SS cases was 4.07 (95 percent CI, 2.04 to 8.09) for PE, 2.80 (1.27 to 6.17) for DVT and 2.92 (1.66 to 5.16) for VTE. The HR matched for age, sex and entry for VTE (8.29; 2.57 to 26.77), PE (4.72; 1.13 to 19.73) and DVT (7.34; 2.80 to 19.25) were highest during the first year after SS diagnosis.

According to researchers, further studies into the involvement of monitoring and prevention of VTE in SS may be warranted.

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Most Read Articles
5 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 6 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
2 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
5 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.