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Roshini Claire Anthony, 05 Oct 2017

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Risk of VTE higher in patients with primary Sjögren syndrome

31 Aug 2017

Population-based evidence shows a substantially increased risk of venous thromboembolism (VTE) among patients with primary Sjögren syndrome (pSS), especially within the first year after SS diagnosis.

Researchers created a study cohort of all patients with incident SS using a population database that includes all residents of British Columbia, Canada, and up to 10 controls from the general population matched for age, sex and entry time to estimate the future risk and time trends of VTE in individuals with newly diagnosed PSS.

Incidence rates (IRs) of pulmonary embolism (PE), deep vein thrombosis (DVT) and VTE were compared between the two groups according to SS disease duration. Hazard ratio (HR) was also calculated, adjusting for confounders.

Of the 1,175 incident pSS cases (mean age 56.7 years; 87.6 percent women), the respective IRs of PE, DVT and VTE were 3.9, 2.8 and 5.2 per 1,000 person-years. The corresponding rates among controls were 0.9, 0.8 and 1.4 per 1,000 person-years.

In comparison with non-SS individuals, the multivariable HR among SS cases was 4.07 (95 percent CI, 2.04 to 8.09) for PE, 2.80 (1.27 to 6.17) for DVT and 2.92 (1.66 to 5.16) for VTE. The HR matched for age, sex and entry for VTE (8.29; 2.57 to 26.77), PE (4.72; 1.13 to 19.73) and DVT (7.34; 2.80 to 19.25) were highest during the first year after SS diagnosis.

According to researchers, further studies into the involvement of monitoring and prevention of VTE in SS may be warranted.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 4 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
6 days ago
Blood glucose testing every other day in patients with controlled gestational diabetes mellitus (GDM) resulted in higher testing compliance than every day testing, a new study has shown.