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Risk of heart failure elevated in RA patients

15 Mar 2017
New heart failure drug shows promise

Heart failure (HF) that cannot be explained by an increased risk of ischaemic heart disease (IHD) is likely to occur among patients with rheumatoid arthritis (RA), according to a recent study. Additionally, this elevated risk of nonischaemic HF occurs early and is associated with RA severity.

Researchers identified two contemporary cohorts of RA participants from Swedish patient and rheumatology registries. These patients were matched 1:10 to general population comparator participants. Registry linkages were used to evaluate a first-ever HF diagnosis (classified as ischaemic or nonischaemic HF based on IHD presence).

Odds ratios were used to calculate relative risks for a history of HF before RA onset, and hazard ratios (HRs) for relative risks of incident HF in RA.

Prior HF was not associated with RA by the time of RA onset. The overall HRs for subsequent, ischaemic and nonischaemic HF in the new-onset RA cohort were between 1.22 and 1.27. There was a rapid increase in the risk of nonischaemic HF after RA onset contrary to the risk of ischaemic HF.

A correlation existed between high disease activity and all HF types, but it was most pronounced for nonischaemic HF. The HRs for the different HF subtypes in the cohort of patients with RA of any duration were between 1.71 and 1.88.

A previous study revealed that myocardial abnormalities were common in RA patients without known cardiac disease. There was an association between abnormal cardiac MRI and increased RA disease activity, which suggests a role for inflammation in the pathogenesis of myocardial involvement in RA. [Arthritis Res Ther 2010;12:R171]

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.