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Risk of heart failure elevated in RA patients

2 months ago
New heart failure drug shows promise

Heart failure (HF) that cannot be explained by an increased risk of ischaemic heart disease (IHD) is likely to occur among patients with rheumatoid arthritis (RA), according to a recent study. Additionally, this elevated risk of nonischaemic HF occurs early and is associated with RA severity.

Researchers identified two contemporary cohorts of RA participants from Swedish patient and rheumatology registries. These patients were matched 1:10 to general population comparator participants. Registry linkages were used to evaluate a first-ever HF diagnosis (classified as ischaemic or nonischaemic HF based on IHD presence).

Odds ratios were used to calculate relative risks for a history of HF before RA onset, and hazard ratios (HRs) for relative risks of incident HF in RA.

Prior HF was not associated with RA by the time of RA onset. The overall HRs for subsequent, ischaemic and nonischaemic HF in the new-onset RA cohort were between 1.22 and 1.27. There was a rapid increase in the risk of nonischaemic HF after RA onset contrary to the risk of ischaemic HF.

A correlation existed between high disease activity and all HF types, but it was most pronounced for nonischaemic HF. The HRs for the different HF subtypes in the cohort of patients with RA of any duration were between 1.71 and 1.88.

A previous study revealed that myocardial abnormalities were common in RA patients without known cardiac disease. There was an association between abnormal cardiac MRI and increased RA disease activity, which suggests a role for inflammation in the pathogenesis of myocardial involvement in RA. [Arthritis Res Ther 2010;12:R171]

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Most Read Articles
6 days ago
Obesity has a slight and substantial negative impact on the cognitive functioning of healthy individuals and major depressive disorder patients (MDD), respectively, a new study shows.
10 days ago
Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.
4 days ago
Myopia is associated with depressive symptoms in Chinese adults, a new population-based study shows.
4 days ago
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.