Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Risk factors for relapse after discontinuation of antiepileptic drugs

06 Aug 2017

Patients receiving more than one antiepileptic drug (AED) and who had started AED treatment more than 6 months after the first syndrome are at a higher risk of recurrence after discontinuation of medication, a new study has shown.

Of 292 epileptic patients who had been seizure-free for more than 2 years, 97 continued AED while 195 were withdrawn from AED treatment. Among patients who ceased AED treatment, 119 had relapsed, resulting in a relapse rate of 34.4 per 100 person-years.

Compared with patients who did not relapse, those who received first treatment more than 6 months after epilepsy diagnosis (p=0.021) and who had an established aetiology (p=0.03) had significantly higher risks of relapse.

Patients who received more than one type of AED before discontinuation (p=0.083), who were not immediately seizure-free after AED initiation (p=0.063) and who changed AED regimens (p=0.070) were at moderately elevated risks of relapse.

Cox proportional hazard regression showed that those who received more than one type of AED drug (hazard ratio [HR], 2.53; 95 percent CI, 1.24 to 5.16; p=0.011) and whose epilepsy was more than 6 months long before AED initiation (HR, 1.47; 1.004 to 2.15; p=0.048) had higher risks of recurrence after AED withdrawal.

Study participants were recruited from the Department of Neurology in Huashan hospital in Shanghai, China. Epilepsy patients were followed-up through interviews, telephone conversations and medical records.

Only patients between the ages of 14 and 80 years, who had received stable doses of one or two AEDs, and who were seizure-free for at least 2 years were included. Exclusion criteria was a history of irregular AED treatment.

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.