Most Read Articles
3 days ago
Higher circulating levels of docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) appear to be protective against incident atherothrombotic and cardioembolic strokes, respectively, according to a recent study.
Roshini Claire Anthony, 5 days ago

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 5 days ago
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.

Risk factors for CAD, stroke in adults with congenital heart disease

20 Sep 2017

Among ageing adult congenital heart disease (ACHD) patients, traditional atherosclerotic risk factors are associated with coronary artery disease (CAD), while ischaemic stroke is related to factors suggesting a cardioembolic aetiology, a multicentre case–control study has found.

Using the national CONgenital CORvitia (CONCOR) registry, researchers identified 6,904 ACHD patients, among whom 55 had CAD (mean age 55.1 years; 80 percent male) and 56 had stroke (mean age 46.9 years; 46 percent male).

Patients with CAD were matched 1:2 with ACHD patients without CAD based on age, CHD defect group and gender. Patients with ischaemic stroke (or transient ischaemic attack) were similarly matched. The presence of risk factors was determined using medical charts and a standardized questionnaire.

Multivariable logistic regression analysis showed CAD to be associated with traditional atherosclerotic risk factors, such as hypertension (odds ratio [OR], 2.45; 95 percent CI, 1.15 to 5.23), hypercholesterolaemia (OR, 3.99; 1.62 to 9.83) and smoking (OR, 2.25; 1.09 to 4.66).

Stroke, on the other hand, was associated with previous shunt operations (OR, 4.20; 1.36 to 12.9), residual/unclosed septal defects (OR, 2.38; 1.03 to 5.51) and left-sided mechanical valves (OR, 2.67; 1.09 to 6.50). Risk factors for CAD were not associated with stroke.

In light of the present data, researchers called on physicians managing individuals with ACHD to recommend a heart-healthy lifestyle early on.

“Physicians should also be aware of the presence of risk factors such as hypertension and treat according to general guidelines,” researchers added.

Additional studies are needed to determine whether modification of the aforementioned risk factors may prevent acquired cardiovascular disease.

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Most Read Articles
3 days ago
Higher circulating levels of docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) appear to be protective against incident atherothrombotic and cardioembolic strokes, respectively, according to a recent study.
Roshini Claire Anthony, 5 days ago

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 5 days ago
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.